Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304.
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Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phoxA p21-activated kinase-controlled metabolic switch up-regulates phagocyte NADPH oxidasePhosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domainsGlutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular trapsPhosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activationStructure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen speciesActivation and assembly of the NADPH oxidase: a structural perspectivep47phox is required for atherosclerotic lesion progression in ApoE(-/-) miceIn silico phosphorylation of the autoinhibited form of p47(phox): insights into the mechanism of activationp47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseasesA molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase.Arachidonic acid and phosphorylation synergistically induce a conformational change of p47phox to activate the phagocyte NADPH oxidase.Diacylglycerol kinases terminate diacylglycerol signaling during the respiratory burst leading to heterogeneous phagosomal NADPH oxidase activationVascular endothelial growth factor causes translocation of p47phox to membrane ruffles through WAVE1.ESR detection of intraphagosomal superoxide in polymorphonuclear leukocytes using 5-(diethoxyphosphoryl)-5-methyl-l-pyrroline-N-oxide.The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators.Complement-independent Ab-induced peroxide lysis of platelets requires 12-lipoxygenase and a platelet NADPH oxidase pathway.Platelet particle formation by anti GPIIIa49-66 Ab, Ca2+ ionophore A23187, and phorbol myristate acetate is induced by reactive oxygen species and inhibited by dexamethasone blockade of platelet phospholipase A2, 12-lipoxygenase, and NADPH oxidase.Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins.P21-activated kinase in inflammatory and cardiovascular disease.Arachidonic acid induces direct interaction of the p67(phox)-Rac complex with the phagocyte oxidase Nox2, leading to superoxide production.Resistance of macrophages to Mycobacterium avium is induced by alpha2-adrenergic stimulation.Modulation of p47PHOX activity by site-specific phosphorylation: Akt-dependent activation of the NADPH oxidase.Redox signaling at invasive microdomains in cancer cells.Dihydroxyoctadecamonoenoate esters inhibit the neutrophil respiratory burst.Modulation of vascular smooth muscle signaling by reactive oxygen species.NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation.Myristic Acid, A Side Chain of Phorbol Myristate Acetate (PMA), Can Activate Human Polymorphonuclear Leukocytes to Produce Oxygen Radicals More Potently than PMA.Protein Kinase C Epsilon Contributes to NADPH Oxidase Activation in a Pre-Eclampsia Lymphoblast Cell Model.Redox signaling in cardiovascular health and disease.Toona sinensis inhibits LPS-induced inflammation and migration in vascular smooth muscle cells via suppression of reactive oxygen species and NF-κB signaling pathway.Links between innate immunity and normal tissue radiobiology.Targeting microglia-mediated neurotoxicity: the potential of NOX2 inhibitors.Roles for beta II-protein kinase C and RACK1 in positive and negative signaling for superoxide anion generation in differentiated HL60 cells.Protein kinase C-mediated phosphorylation of p47 phox modulates platelet-derived growth factor-induced H2O2 generation and cell proliferation in human umbilical vein endothelial cells.Mechanism of angiotensin II-induced superoxide production in cells reconstituted with angiotensin type 1 receptor and the components of NADPH oxidase.Perturbation of actin dynamics induces NF-kappaB activation in myelomonocytic cells through an NADPH oxidase-dependent pathway.Cross-talk between IRAK-4 and the NADPH oxidase.Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.
P2860
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P2860
Activation of the leukocyte NADPH oxidase by phorbol ester requires the phosphorylation of p47PHOX on serine 303 or 304.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Activation of the leukocyte NA ...... p47PHOX on serine 303 or 304.
@en
Activation of the leukocyte NA ...... p47PHOX on serine 303 or 304.
@nl
type
label
Activation of the leukocyte NA ...... p47PHOX on serine 303 or 304.
@en
Activation of the leukocyte NA ...... p47PHOX on serine 303 or 304.
@nl
prefLabel
Activation of the leukocyte NA ...... p47PHOX on serine 303 or 304.
@en
Activation of the leukocyte NA ...... p47PHOX on serine 303 or 304.
@nl
P2093
P2860
P356
P1476
Activation of the leukocyte NA ...... p47PHOX on serine 303 or 304.
@en
P2093
P2860
P304
P356
10.1074/JBC.273.16.9539
P407
P577
1998-04-01T00:00:00Z