T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
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Structure-function insights reveal the human ribosome as a cancer target for antibiotics.Premalignant PTEN-deficient thymocytes activate microRNAs miR-146a and miR-146b as a cellular defense against malignant transformation.Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.Deletion of Snai2 and Snai3 results in impaired physical development compounded by lymphocyte deficiency.A PI3K p110β-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis.Regulation and function of mTOR signalling in T cell fate decisions.Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy.Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migrationMetabolism, migration and memory in cytotoxic T cells.Regulation of glucose metabolism in T cells: new insight into the role of Phosphoinositide 3-kinases.A three-signal model of T-cell lymphoma pathogenesisOncogenic PTEN functions and models in T-cell malignancies.Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy.Microenvironmental cues for T-cell acute lymphoblastic leukemia development.Challenging perspectives on the cellular origins of lymphoma.Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice.The role of the PI3K-AKT kinase pathway in T-cell development beyond the beta checkpoint.Regulation of T cell homeostasis and responses by pten.Conditional deletion of PTEN in peripheral T cells augments TCR-mediated activation but does not abrogate CD28 dependency or prevent anergy induction.Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma.Phosphoinositide-dependent kinase 1 controls migration and malignant transformation but not cell growth and proliferation in PTEN-null lymphocytes.Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice.Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity.Iron chelation: an adjuvant therapy to target metabolism, growth and survival of murine PTEN-deficient T lymphoma and human T lymphoblastic leukemia/lymphoma.
P2860
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P2860
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
@en
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
@nl
type
label
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
@en
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
@nl
prefLabel
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
@en
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
@nl
P2860
P356
P1433
P1476
T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus.
@en
P2093
T J Hagenbeek
P2860
P2888
P304
P356
10.1038/SJ.LEU.2405056
P577
2007-11-29T00:00:00Z
P5875
P6179
1019003933