Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
about
A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damageEukaryotic DNA ligases: structural and functional insightsBRCT domains: easy as one, two, threeStructural and functional interaction between the human DNA repair proteins DNA ligase IV and XRCC4Forkhead-associated domain of yeast Xrs2, a homolog of human Nbs1, promotes nonhomologous end joining through interaction with a ligase IV partner protein, Lif1Modes of interaction among yeast Nej1, Lif1 and Dnl4 proteins and comparison to human XLF, XRCC4 and Lig4Structure of C-terminal Tandem BRCT Repeats of Rtt107 Protein Reveals Critical Role in Interaction with Phosphorylated Histone H2A during DNA Damage RepairStructural Insights into the Role of Domain Flexibility in Human DNA Ligase IVYeast Nej1 is a key participant in the initial end binding and final ligation steps of nonhomologous end joining.Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae.Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection.Gene variants of XRCC4 and XRCC3 and their association with risk for urothelial bladder cancerDe Novo modeling in cryo-EM density maps with Pathwalking.Model-building strategies for low-resolution X-ray crystallographic dataDNA ligases as therapeutic targetsNon-homologous end joining: Common interaction sites and exchange of multiple factors in the DNA repair process.Genetic polymorphisms of DNA double-strand break repair pathway genes and glioma susceptibility.Saccharomyces cerevisiae DNA ligase IV supports imprecise end joining independently of its catalytic activity.Tandem BRCT Domains: DNA's Praetorian Guard.Recognition and repair of chemically heterogeneous structures at DNA endsYeast DNA ligase IV mutations reveal a nonhomologous end joining function of BRCT1 distinct from XRCC4/Lif1 binding.Nonhomologous chromosomal integration of foreign DNA is completely dependent on MUS-53 (human Lig4 homolog) in Neurospora.Electron microscopy visualization of DNA-protein complexes formed by Ku and DNA ligase IVGenome-wide screens for sensitivity to ionizing radiation identify the fission yeast nonhomologous end joining factor Xrc4.Ku heterodimer-independent end joining in Trypanosoma brucei cell extracts relies upon sequence microhomology.Restricting the ligation step of non-homologous end-joining.Evidence for a structural relationship between BRCT domains and the helicase domains of the replication initiators encoded by the Polyomaviridae and Papillomaviridae families of DNA tumor viruses.Genetic susceptibility to renal cell carcinoma: the role of DNA double-strand break repair pathwayDNA repair pathways in trypanosomatids: from DNA repair to drug resistance.Repair of double-strand breaks by end joining.The spatial organization of non-homologous end joining: from bridging to end joining.Consider the workhorse: Nonhomologous end-joining in budding yeast.Structural biology of DNA repair: spatial organisation of the multicomponent complexes of nonhomologous end joining.Evolutionary and functional conservation of the DNA non-homologous end-joining protein, XLF/Cernunnos.
P2860
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P2860
Structure of an Xrcc4-DNA ligase IV yeast ortholog complex reveals a novel BRCT interaction mode.
description
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name
Structure of an Xrcc4-DNA liga ...... a novel BRCT interaction mode.
@en
Structure of an Xrcc4-DNA liga ...... a novel BRCT interaction mode.
@nl
type
label
Structure of an Xrcc4-DNA liga ...... a novel BRCT interaction mode.
@en
Structure of an Xrcc4-DNA liga ...... a novel BRCT interaction mode.
@nl
prefLabel
Structure of an Xrcc4-DNA liga ...... a novel BRCT interaction mode.
@en
Structure of an Xrcc4-DNA liga ...... a novel BRCT interaction mode.
@nl
P2093
P50
P1433
P1476
Structure of an Xrcc4-DNA liga ...... a novel BRCT interaction mode.
@en
P2093
Andrew S Doré
Bancinyane L Sibanda
Luca Pellegrini
P304
P356
10.1016/J.DNAREP.2005.11.004
P577
2006-01-18T00:00:00Z