Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
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Quantitative analysis of HSP90-client interactions reveals principles of substrate recognitionIdentification of a novel HSP70-binding cochaperone critical to HSP90-mediated activation of small serine/threonine kinaseStructural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 ProteinDynamics-Driven Allostery in Protein KinasesErbB polymorphisms: insights and implications for response to targeted cancer therapeuticsStructure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Statistical method on nonrandom clustering with application to somatic mutations in cancer.Identification of prolidase as a high affinity ligand of the ErbB2 receptor and its regulation of ErbB2 signaling and cell growthHer4 and Her2/neu tyrosine kinase domains dimerize and activate in a reconstituted in vitro systemAtomistic insights into regulatory mechanisms of the HER2 tyrosine kinase domain: a molecular dynamics study.HER2 stabilizes EGFR and itself by altering autophosphorylation patterns in a manner that overcomes regulatory mechanisms and promotes proliferative and transformation signaling.Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment.Acquired substrate preference for GAB1 protein bestows transforming activity to ERBB2 kinase lung cancer mutants.Effect of acute acid-base disturbances on ErbB1/2 tyrosine phosphorylation in rabbit renal proximal tubules.Lessons to be Learned: The Molecular Basis of Kinase-Targeted Therapies and Drug Resistance in Non-Small Cell Lung Cancer.Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.Gatekeeper tyrosine phosphorylation is autoinhibitory for Symbiosis Receptor Kinase.
P2860
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P2860
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
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2007 nî lūn-bûn
@nan
2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
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2007年學術文章
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2007年學術文章
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name
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
@en
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
@nl
type
label
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
@en
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
@nl
prefLabel
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
@en
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
@nl
P2093
P2860
P356
P1476
Mutational activation of ErbB2 reveals a new protein kinase autoinhibition mechanism.
@en
P2093
Gibbes R Johnson
Jinhui Ding
Nikolay A Spiridonov
Richard C Johnson
Ying-Xin Fan
P2860
P304
P356
10.1074/JBC.M708116200
P407
P577
2007-11-26T00:00:00Z