P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation. - Wikidata - wikimedia - TriplyDB

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.

P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.

http://www.wikidata.org/entity/Q46890870

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Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes A mouse model uncovers LKB1 as an UVB-induced DNA damage sensor mediating CDKN1A (p21WAF1/CIP1) degradation The Role of PCNA Posttranslational Modifications in Translesion Synthesis Eukaryotic translesion polymerases and their roles and regulation in DNA damage tolerance Examination of the expanding pathways for the regulation of p21 expression and activity.CRL4Cdt2: master coordinator of cell cycle progression and genome stability p21 in cancer: intricate networks and multiple activities Regulation of proliferating cell nuclear antigen ubiquitination in mammalian cells.Two-polymerase mechanisms dictate error-free and error-prone translesion DNA synthesis in mammals Role of p62 in the suppression of inflammatory cytokine production by adiponectin in macrophages: Involvement of autophagy and p21/Nrf2 axis.Coordinating DNA polymerase traffic during high and low fidelity synthesis.Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells PCNA ubiquitination is important, but not essential for translesion DNA synthesis in mammalian cells.PCNA-coupled p21 degradation after DNA damage: The exception that confirms the rule?Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.Analysis of the tolerance to DNA alkylating damage in MEC1 and RAD53 checkpoint mutants of Saccharomyces cerevisiae.APC/CCdh1-dependent proteolysis of USP1 regulates the response to UV-mediated DNA damage.N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) triggers MSH2 and Cdt2 protein-dependent degradation of the cell cycle and mismatch repair (MMR) inhibitor protein p21Waf1/Cip1 hHR23B is required for genotoxic-specific activation of p53 and apoptosis.Caffeine abolishes the ultraviolet-induced REV3 translesion replication pathway in mouse cells.DNA damage tolerance pathway involving DNA polymerase ι and the tumor suppressor p53 regulates DNA replication fork progression.PCNA modifications for regulation of post-replication repair pathways UV-triggered p21 degradation facilitates damaged-DNA replication and preserves genomic stability DNA polymerase zeta cooperates with polymerases kappa and iota in translesion DNA synthesis across pyrimidine photodimers in cells from XPV patients.SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage.Cyclin Kinase-independent role of p21CDKN1A in the promotion of nascent DNA elongation in unstressed cells.CtIP is required for DNA damage-dependent induction of P21.DNA polymerase eta and chemotherapeutic agents.Roles of sequential ubiquitination of PCNA in DNA-damage tolerance.Ubiquitin-family modifications in the replication of DNA damage.CRL Ubiquitin Ligases and DNA Damage Response.Regulation of human DNA polymerase delta in the cellular responses to DNA damage.The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.Role of the mammalian SWI/SNF chromatin remodeling complex in the cellular response to UV damage.The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight.Regulation of Rad6/Rad18 Activity During DNA Damage Tolerance.Hdm2- and proteasome-dependent turnover limits p21 accumulation during S phase Androgen receptor primes prostate cancer cells to apoptosis through down-regulation of basal p21 expression.PIDD orchestrates translesion DNA synthesis in response to UV irradiation.

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P21Cip1/WAF1 downregulation is required for efficient PCNA ubiquitination after UV irradiation.

http://www.wikidata.org/entity/Q46890870

description

2006 nî lūn-bûn

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P21Cip1/WAF1 downregulation is ...... tination after UV irradiation.

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P21Cip1/WAF1 downregulation is ...... tination after UV irradiation.

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P21Cip1/WAF1 downregulation is ...... tination after UV irradiation.

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P21Cip1/WAF1 downregulation is ...... tination after UV irradiation.

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P21Cip1/WAF1 downregulation is ...... tination after UV irradiation.

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P21Cip1/WAF1 downregulation is ...... tination after UV irradiation.

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Gottifredi V

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Podhajcer O

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Prives C

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P2860

The DNA repair endonuclease XPG binds to proliferating cell nuclear antigen (PCNA) and shares sequence elements with the PCNA-binding regions of FEN-1 and cyclin-dependent kinase inhibitor p21

A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination

p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex

Actinomycin and DNA transcription

Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen

Structure of the C-terminal region of p21(WAF1/CIP1) complexed with human PCNA

RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO.

Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase

Replication protein A phosphorylation and the cellular response to DNA damage

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protein ubiquitination