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Activation of the lysosome-associated p61Hck isoform triggers the biogenesis of podosomesHematopoietic cell kinase (Hck) isoforms and phagocyte duties - from signaling and actin reorganization to migration and phagocytosisThree-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysisMycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infectionContractility of the cell rear drives invasion of breast tumor cells in 3D Matrigel.Macrophage mesenchymal migration requires podosome stabilization by filamin AHck contributes to bone homeostasis by controlling the recruitment of osteoclast precursors.Queuosine biosynthesis is required for sinorhizobium meliloti-induced cytoskeletal modifications on HeLa Cells and symbiosis with Medicago truncatula.Spontaneous contractility-mediated cortical flow generates cell migration in three-dimensional environmentsMycobacterial p(1)-type ATPases mediate resistance to zinc poisoning in human macrophages.Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis.Matrix invasion by tumour cells: a focus on MT1-MMP trafficking to invadopodia.C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells.HIV-1 reprograms the migration of macrophages.Implication of metastasis suppressor NM23-H1 in maintaining adherens junctions and limiting the invasive potential of human cancer cells.Macrophage podosomes go 3D.Diaphanous-related formins are required for invadopodia formation and invasion of breast tumor cells.MT1-MMP-dependent invasion is regulated by TI-VAMP/VAMP7.Tyrosine-phosphorylated STAT5 accumulates on podosomes in Hck-transformed fibroblasts and chronic myeloid leukemia cells.Evaluation of the force and spatial dynamics of macrophage podosomes by multi-particle tracking.Fungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules.Working together: spatial synchrony in the force and actin dynamics of podosome first neighbors.HIV-1 Nef alters podosomes and promotes the mesenchymal migration in human macrophages.Podosome Force Generation Machinery: A Local Balance between Protrusion at the Core and Traction at the Ring.Lymphocyte-specific protein 1 regulates mechanosensory oscillation of podosomes and actin isoform-based actomyosin symmetry breaking.Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.Podosomes, But Not the Maturation Status, Determine the Protease-Dependent 3D Migration in Human Dendritic Cells.The oncogenic activity of the Src family kinase Hck requires the cooperative action of the plasma membrane- and lysosome-associated isoforms.The C-Type Lectin Receptor DC-SIGN Has an Anti-Inflammatory Role in Human M(IL-4) Macrophages in Response to Mycobacterium tuberculosis.Nanoscale Forces during Confined Cell MigrationProtrusion Force Microscopy: A Method to Quantify Forces Developed by Cell ProtrusionsProtrusion force microscopy reveals oscillatory force generation and mechanosensing activity of human macrophage podosomesMatrix Architecture Dictates Three-Dimensional Migration Modes of Human Macrophages: Differential Involvement of Proteases and Podosome-Like StructuresRe-arrangements of podosome structures are observed when Hck is activated in myeloid cellsFrustrated endocytosis controls contractility-independent mechanotransduction at clathrin-coated structuresThe Protease-Dependent Mesenchymal Migration of Tumor-Associated Macrophages as a Target in Cancer ImmunotherapyProbing the mechanical landscape - new insights into podosome architecture and mechanicsTuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in MacrophagesHIV-1-Infected Human Macrophages, by Secreting RANK-L, Contribute to Enhanced Osteoclast Recruitment
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P50
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onderzoeker
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researcher ORCID ID = 0000-0003-2884-1744
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name
Renaud Poincloux
@ast
Renaud Poincloux
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Renaud Poincloux
@es
Renaud Poincloux
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type
label
Renaud Poincloux
@ast
Renaud Poincloux
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Renaud Poincloux
@es
Renaud Poincloux
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prefLabel
Renaud Poincloux
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Renaud Poincloux
@en
Renaud Poincloux
@es
Renaud Poincloux
@nl
P106
P108
P31
P496
0000-0003-2884-1744