CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans. - Wikidata - wikimedia - TriplyDB

CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.

CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.

http://www.wikidata.org/entity/Q47068715

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The Caenorhabditis elegans cell-cycle regulator ZYG-11 defines a conserved family of CUL-2 complex components VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases Analysis of CUL-5 expression in breast epithelial cells, breast cancer cell lines, normal tissues and tumor tissues The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions Atlas on substrate recognition subunits of CRL2 E3 ligases CRL2(LRR-1) E3-ligase regulates proliferation and progression through meiosis in the Caenorhabditis elegans germline A novel mutation in β integrin reveals an integrin-mediated interaction between the extracellular matrix and cki-1/p27KIP1 A role for Saccharomyces cerevisiae Cul8 ubiquitin ligase in proper anaphase progression.A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivo Cell cycle regulators control centrosome elimination during oogenesis in Caenorhabditis elegans.Gene expression profiles in acute myeloid leukemia with common translocations using SAGE.E1 ubiquitin-activating enzyme UBA-1 plays multiple roles throughout C. elegans development.A complex regulatory network coordinating cell cycles during C. elegans development is revealed by a genome-wide RNAi screen.Insulin signaling promotes germline proliferation in C. elegans.The CRL2LRR-1 ubiquitin ligase regulates cell cycle progression during C. elegans development.Null mutation of AtCUL1 causes arrest in early embryogenesis in Arabidopsis.Nedd8 on cullin: building an expressway to protein destruction.Irises: A practical tool for image-based analysis of cellular DNA content.C. elegans CAND-1 regulates cullin neddylation, cell proliferation and morphogenesis in specific tissues Cullins and cancer.Cell proliferation and growth in C. elegans.Malignant worms: what cancer research can learn from C. elegans.CRL2(LRR-1) targets a CDK inhibitor for cell cycle control in C. elegans and actin-based motility regulation in human cells Cyclin E and CDK-2 regulate proliferative cell fate and cell cycle progression in the C. elegans germline.The cyclin-dependent kinase inhibitors, cki-1 and cki-2, act in overlapping but distinct pathways to control cell cycle quiescence during C. elegans development.Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans.The Caenorhabditis elegans replication licensing factor CDT-1 is targeted for degradation by the CUL-4/DDB-1 complex Targeting Homologous Recombination in Notch-Driven C. elegans Stem Cell and Human Tumors.Oncogenic aberrations of cullin-dependent ubiquitin ligases.Identification of Wnt Pathway Target Genes Regulating the Division and Differentiation of Larval Seam Cells and Vulval Precursor Cells in Caenorhabditis elegans mir-35 is involved in intestine cell G1/S transition and germ cell proliferation in C. elegans.A CUL-2 ubiquitin ligase containing three FEM proteins degrades TRA-1 to regulate C. elegans sex determination Co-expressed Cyclin D variants cooperate to regulate proliferation of germline nuclei in a syncytium.Reciprocal Changes in Phosphoenolpyruvate Carboxykinase and Pyruvate Kinase with Age Are a Determinant of Aging in Caenorhabditis elegans.Cyclin-dependent kinases in C. elegans.The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia.Cyclin-dependent kinase inhibitors in yeast, animals, and plants: a functional comparison.Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially.A role for Arf1 in mitotic Golgi disassembly, chromosome segregation, and cytokinesis.Levels of the ubiquitin ligase substrate adaptor MEL-26 are inversely correlated with MEI-1/katanin microtubule-severing activity during both meiosis and mitosis.

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CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans.

http://www.wikidata.org/entity/Q47068715

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1999 nî lūn-bûn

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CUL-2 is required for the G1-t ...... ion in Caenorhabditis elegans.

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CUL-2 is required for the G1-t ...... ion in Caenorhabditis elegans.

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type

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CUL-2 is required for the G1-t ...... ion in Caenorhabditis elegans.

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CUL-2 is required for the G1-t ...... ion in Caenorhabditis elegans.

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CUL-2 is required for the G1-t ...... ion in Caenorhabditis elegans.

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CUL-2 is required for the G1-t ...... ion in Caenorhabditis elegans.

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Nature Cell Biology

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CUL-2 is required for the G1-t ...... ion in Caenorhabditis elegans.

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Feng H

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Gu S

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Kipreos ET

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Punkosdy G

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Seabolt EK

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P2860

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family

Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2

The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

The ubiquitin system

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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486-492

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10.1038/70272

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8

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1

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12712972

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10587644

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Caenorhabditis elegans