An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation.
about
Irx1 and Irx2 are coordinately expressed and regulated by retinoic acid, TGFβ and FGF signaling during chick hindlimb developmentTranscriptional enhancers: functional insights and role in human diseaseScrutinizing the FTO locus: compelling evidence for a complex, long-range regulatory contextOrganogenesis in deep time: A problem in genomics, development, and paleontologyAn ancient genomic regulatory block conserved across bilaterians and its dismantling in tetrapods by retrogene replacementPlant metabolic clusters - from genetics to genomics.Dissecting the transcriptional regulatory properties of human chromosome 16 highly conserved non-coding regionsRecessive mutations in a distal PTF1A enhancer cause isolated pancreatic agenesis.Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.A novel gain-of-function mutation of the proneural IRX1 and IRX2 genes disrupts axis elongation in the Araucana rumpless chicken.Differences in enhancer activity in mouse and zebrafish reporter assays are often associated with changes in gene expression.Genome wide analysis reveals Zic3 interaction with distal regulatory elements of stage specific developmental genes in zebrafish.Identification and computational analysis of gene regulatory elements.The epigenome in early vertebrate development.Widespread recurrent evolution of genomic features.Complete re-sequencing of a 2Mb topological domain encompassing the FTO/IRXB genes identifies a novel obesity-associated region upstream of IRX5.North Carolina Macular Dystrophy Is Caused by Dysregulation of the Retinal Transcription Factor PRDM13.Impact of copy number variations (CNVs) on long-range gene regulation at the HoxD locus.Delineation of metabolic gene clusters in plant genomes by chromatin signatures.Chromatin organization and global regulation of Hox gene clusters.Evaluation of IRX Genes and Conserved Noncoding Elements in a Region on 5p13.3 Linked to Families with Familial Idiopathic Scoliosis and Kyphosis.Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks.A common genetic variant within SCN10A modulates cardiac SCN5A expressionEvolution of sound and balance perception: innovations that aggregate single hair cells into the ear and transform a gravistatic sensor into the organ of corti.Deep conservation of cis-regulatory elements in metazoans.Extensive conservation of ancient microsynteny across metazoans due to cis-regulatory constraints.Irx1 regulates dental outer enamel epithelial and lung alveolar type II epithelial differentiationCTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart.Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation.The genomic landscape of cohesin-associated chromatin interactions.Functional and topological characteristics of mammalian regulatory domains.Three Dimensional Organization of Genome Might Have Guided the Dynamics of Gene Order Evolution in Eukaryotes.Structure and function of the Nppa-Nppb cluster locus during heart development and disease.Expression patterns of Irx genes in the developing chick inner ear.sox21a directs lateral line patterning by modulating FGF signaling.
P2860
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P2860
An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
An evolutionarily conserved th ...... ncer sharing and coregulation.
@en
An evolutionarily conserved th ...... ncer sharing and coregulation.
@nl
type
label
An evolutionarily conserved th ...... ncer sharing and coregulation.
@en
An evolutionarily conserved th ...... ncer sharing and coregulation.
@nl
prefLabel
An evolutionarily conserved th ...... ncer sharing and coregulation.
@en
An evolutionarily conserved th ...... ncer sharing and coregulation.
@nl
P50
P356
P1476
An evolutionarily conserved th ...... ancer sharing and coregulation
@en
P2093
Erik Splinter
M Eva Alonso
P2888
P356
10.1038/NCOMMS1301
P407
P577
2011-01-01T00:00:00Z