about
A peptide filtering relation quantifies MHC class I peptide optimizationAssembly and antigen-presenting function of MHC class I molecules in cells lacking the ER chaperone calreticulinTwo polymorphisms facilitate differences in plasticity between two chicken major histocompatibility complex class I proteinsPeptide-independent stabilization of MHC class I molecules breaches cellular quality controlOptimization of the MHC class I peptide cargo is dependent on tapasinAssembly and export of MHC class I peptide ligandsSelector function of MHC I molecules is determined by protein plasticityThe oxidoreductase ERp57 efficiently reduces partially folded in preference to fully folded MHC class I moleculesInduction of protective antitumor immunity through attenuation of ERAAP functionTAPBPR alters MHC class I peptide presentation by functioning as a peptide exchange catalystNaturally processed HLA class II peptides reveal highly conserved immunogenic flanking region sequence preferences that reflect antigen processing rather than peptide-MHC interactions.Solid-phase synthesis of 89 polyamine-based cationic lipids for DNA delivery to mammalian cells.DNA transfection screening from single beads.TAPBPR bridges UDP-glucose:glycoprotein glucosyltransferase 1 onto MHC class I to provide quality control in the antigen presentation pathway.MHC-restricted T cell responses against posttranslationally modified peptide antigens.The cell biology of MHC class I antigen presentation.Functionally distinct ERAP1 allotype combinations distinguish individuals with Ankylosing Spondylitis.Folding of an MHC class II-restricted tumor antigen controls its antigenicity via MHC-guided processing.The processing of antigens delivered as DNA vaccines.Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis.Viral antigen mediated NKp46 activation of NK cells results in tumor rejection via NK-DC crosstalk.Breast cancer is a promising target for vaccination using cancer-testis antigens known to elicit immune responses.Proteasomes, TAP, and endoplasmic reticulum-associated aminopeptidase associated with antigen processing control CD4+ Th cell responses by regulating indirect presentation of MHC class II-restricted cytoplasmic antigensLectin-deficient calreticulin retains full functionality as a chaperone for class I histocompatibility molecules.Increased Valency of Conserved-mosaic Vaccines Enhances the Breadth and Depth of Epitope Recognition.ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activityNaturally occurring ERAP1 haplotypes encode functionally distinct alleles with fine substrate specificity.Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function.The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding.ERAP1 in the pathogenesis of ankylosing spondylitis.Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function.The Clonal Invariant NKT Cell Repertoire in People with Type 1 Diabetes Is Characterized by a Loss of Clones Expressing High-Affinity TCRs.Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen.Tapasin dependence of major histocompatibility complex class I molecules correlates with their conformational flexibility.Differential suppression of tumor-specific CD8+ T cells by regulatory T cells.Quantitative and qualitative iNKT repertoire associations with disease susceptibility and outcome in macaque tuberculosis infection.Generation of a functional, soluble tapasin protein from an alternatively spliced mRNA.Lymphoblastoid cells express HLA-B27 homodimers both intracellularly and at the cell surface following endosomal recycling.Evidence for successive peptide binding and quality control stages during MHC class I assembly.
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Tim Elliott
@ast
Tim Elliott
@en
Tim Elliott
@es
Tim Elliott
@nl
Tim Elliott
@sl
type
label
Tim Elliott
@ast
Tim Elliott
@en
Tim Elliott
@es
Tim Elliott
@nl
Tim Elliott
@sl
prefLabel
Tim Elliott
@ast
Tim Elliott
@en
Tim Elliott
@es
Tim Elliott
@nl
Tim Elliott
@sl
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P21
P2798
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P496
0000-0003-1097-0222