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The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathwayRelease of eIF6 (p27BBP) from the 60S subunit allows 80S ribosome assemblyIncreased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamicseIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcriptionLoss of the actin remodeler Eps8 causes intestinal defects and improved metabolic status in micecAMP and in vivo hypoxia induce tob, ifr1, and fos expression in erythroid cells of the chick embryo.The endocytic adaptor Eps15 controls marginal zone B cell numbersBDNF binding to truncated trkB.T1 does not affect gene expression.Formation of nuclear matrix filaments by p27(BBP)/eIF6.
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Nina Offenhäuser
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Nina Offenhäuser
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Nina Offenhäuser
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