A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a mechanism of resistance to the anticancer drug bleomycin.
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The uses of genome-wide yeast mutant collectionsLoss of a 20S proteasome activator in Saccharomyces cerevisiae downregulates genes important for genomic integrity, increases DNA damage, and selectively sensitizes cells to agents with diverse mechanisms of actionProteasome nuclear activity affects chromosome stability by controlling the turnover of Mms22, a protein important for DNA repair.Novel role for the Saccharomyces cerevisiae oligopeptide transporter Opt2 in drug detoxification.Rrd1 isomerizes RNA polymerase II in response to rapamycinAgp2, a member of the yeast amino acid permease family, positively regulates polyamine transport at the transcriptional level.Yeast toxicogenomics: genome-wide responses to chemical stresses with impact in environmental health, pharmacology, and biotechnologySuppression of sensitivity to drugs and antibiotics by high external cation concentrations in fission yeastComplementation of the Yeast Model System Reveals that Caenorhabditis elegans OCT-1 Is a Functional Transporter of AnthracyclinesMembrane transporters and protein traffic networks differentially affecting metal tolerance: a genomic phenotyping study in yeast.Genomewide screen reveals a wide regulatory network for di/tripeptide utilization in Saccharomyces cerevisiae.Transcriptome profiling of Saccharomyces cerevisiae mutants lacking C2H2 zinc finger proteinsRNA-directed DNA methylation and plant development require an IWR1-type transcription factorGenetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae.The human carnitine transporter SLC22A16 mediates high affinity uptake of the anticancer polyamine analogue bleomycin-A5A novel, drug-based, cellular assay for the activity of neurotoxic mutants of the prion protein.RDM4 modulates cold stress resistance in Arabidopsis partially through the CBF-mediated pathway.The peptidyl prolyl isomerase Rrd1 regulates the elongation of RNA polymerase II during transcriptional stresses.Salivary histatin 5 internalization by translocation, but not endocytosis, is required for fungicidal activity in Candida albicans.Saccharomyces cerevisiae as a model system to study the response to anticancer agents.The protein transportation pathway from Golgi to vacuoles via endosomes plays a role in enhancement of methylmercury toxicity.A genomic screen revealing the importance of vesicular trafficking pathways in genome maintenance and protection against genotoxic stress in diploid Saccharomyces cerevisiae cellsRapid Identification of Chemoresistance Mechanisms Using Yeast DNA Mismatch Repair Mutants.Genomic profiling of fungal cell wall-interfering compounds: identification of a common gene signature.Bleomycins: towards better therapeutics.Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres.Broad network-based predictability of Saccharomyces cerevisiae gene loss-of-function phenotypes.Heterozygous screen in Saccharomyces cerevisiae identifies dosage-sensitive genes that affect chromosome stability.The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicinDrug uptake, lipid rafts, and vesicle trafficking modulate resistance to an anticancer lysophosphatidylcholine analogue in yeastMechanistic studies on bleomycin-mediated DNA damage: multiple binding modes can result in double-stranded DNA cleavageGenomic approaches for investigating mechanisms of genotoxicity.Pingyangmycin and Bleomycin Share the Same Cytotoxicity Pathway.Exploring Quantitative Yeast Phenomics with Single-Cell Analysis of DNA Damage Foci.Loss of regulators of vacuolar ATPase function and ceramide synthesis results in multidrug sensitivity in Schizosaccharomyces pombe.Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae.Characterization of a transport and detoxification pathway for the antitumour drug bleomycin in Saccharomyces cerevisiae.Learning regulatory programs that accurately predict differential expression with MEDUSA.The isomerase Rrd1 mediates rapid loss of the Sgs1 helicase in response to rapamycin.AGP2 encodes the major permease for high affinity polyamine import in Saccharomyces cerevisiae.
P2860
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P2860
A genome-wide screen in Saccharomyces cerevisiae reveals altered transport as a mechanism of resistance to the anticancer drug bleomycin.
description
2004 nî lūn-bûn
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2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
A genome-wide screen in Saccha ...... the anticancer drug bleomycin.
@en
A genome-wide screen in Saccha ...... the anticancer drug bleomycin.
@nl
type
label
A genome-wide screen in Saccha ...... the anticancer drug bleomycin.
@en
A genome-wide screen in Saccha ...... the anticancer drug bleomycin.
@nl
prefLabel
A genome-wide screen in Saccha ...... the anticancer drug bleomycin.
@en
A genome-wide screen in Saccha ...... the anticancer drug bleomycin.
@nl
P2093
P1433
P1476
A genome-wide screen in Saccha ...... the anticancer drug bleomycin.
@en
P2093
Anick Leduc
Dindial Ramotar
Matthias Peter
Mustapha Aouida
Nicolas Pagé
P304
P356
10.1158/0008-5472.CAN-03-2729
P407
P577
2004-02-01T00:00:00Z