Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.
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SIRT1 negatively regulates the mammalian target of rapamycinTBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translationThe TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathwayMuscle atrophy in transgenic mice expressing a human TSC1 transgeneIdentification and characterization of the interaction between tuberin and 14-3-3zetaThe TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeletonRegulation of TSC2 by 14-3-3 bindingUpregulation of the mammalian target of rapamycin complex 1 pathway by Ras homolog enriched in brain in pancreatic beta-cells leads to increased beta-cell mass and prevention of hyperglycemiaSignaling by target of rapamycin proteins in cell growth controlRegulation of mTOR and cell growth in response to energy stress by REDD1.Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signalingRegulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complexAmino acids as regulators of gene expressionTumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinaseThe Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysisResveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTORThe tuberous sclerosis complexAn emerging role for TOR signaling in mammalian tissue and stem cell physiologyRegulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathwayThe TSC1-TSC2 complex: a molecular switchboard controlling cell growthRheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signalingHypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttlingIdentification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size controlThe Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signalingRegulation of mTORC1 by PI3K signalingNutritional regulation of stem and progenitor cells in DrosophilaMechanisms of TSC-mediated control of synapse assembly and axon guidanceA model of muscle atrophy based on live microscopy of muscle remodelling in Drosophila metamorphosis.Scaling the Drosophila Wing: TOR-Dependent Target Gene Access by the Hippo Pathway Transducer YorkieRag proteins regulate amino-acid-induced mTORC1 signalling.Drugging the addict: non-oncogene addiction as a target for cancer therapyRheb is a direct target of the tuberous sclerosis tumour suppressor proteinsCell cycle-regulated phosphorylation of hamartin, the product of the tuberous sclerosis complex 1 gene, by cyclin-dependent kinase 1/cyclin BPam and its ortholog highwire interact with and may negatively regulate the TSC1.TSC2 complexPhosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberinRegulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independentAssociation of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growthInteraction of FoxO1 and TSC2 induces insulin resistance through activation of the mammalian target of rapamycin/p70 S6K pathway
P2860
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P2860
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh-hant
name
Drosophila Tsc1 functions with ...... proliferation, and organ size.
@en
Drosophila Tsc1 functions with ...... proliferation, and organ size.
@nl
type
label
Drosophila Tsc1 functions with ...... proliferation, and organ size.
@en
Drosophila Tsc1 functions with ...... proliferation, and organ size.
@nl
prefLabel
Drosophila Tsc1 functions with ...... proliferation, and organ size.
@en
Drosophila Tsc1 functions with ...... proliferation, and organ size.
@nl
P1433
P1476
Drosophila Tsc1 functions with ...... proliferation, and organ size.
@en
P304
P356
10.1016/S0092-8674(01)00333-6
P407
P577
2001-05-01T00:00:00Z