Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B-mediated drug-drug interactions using population pharmacokinetic modelling and simulation.

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Quantitative Prediction of OATP-Mediated Drug-Drug Interactions With Model-Based Analysis of Endogenous Biomarker Kinetics

P2860

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P2860

Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B-mediated drug-drug interactions using population pharmacokinetic modelling and simulation.

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name

Gaining mechanistic insight in ...... etic modelling and simulation.

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Gaining mechanistic insight in ...... etic modelling and simulation.

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Gaining mechanistic insight in ...... etic modelling and simulation.

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Gaining mechanistic insight in ...... etic modelling and simulation.

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Gaining mechanistic insight in ...... etic modelling and simulation.

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Gaining mechanistic insight in ...... etic modelling and simulation.

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P1476

Gaining mechanistic insight in ...... etic modelling and simulation.

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P2093

Aleksandra Galetin

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Hong Shen

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Karelle Ménochet

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Kayode Ogungbenro

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Shelby Barnett

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W Griffith Humphreys

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ITC recommendations for transporter kinetic parameter estimation and translational modeling of transport-mediated PK and DDIs in humans

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Combining the 'bottom up' and 'top down' approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data

Reduced physiologically-based pharmacokinetic model of repaglinide: impact of OATP1B1 and CYP2C8 genotype and source of in vitro data on the prediction of drug-drug interaction risk.

DAISY: a new software tool to test global identifiability of biological and physiological systems

Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.

Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin.

Population pharmacokinetics of rifampin in pulmonary tuberculosis patients, including a semimechanistic model to describe variable absorption

Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.

Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.

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564-574

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scholarly article

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10.1002/CPT.983

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English

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104

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Yurong Lai

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2017-12-15T00:00:00Z

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29243231

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6175062

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Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B-mediated drug-drug interactions using population pharmacokinetic modelling and simulation.

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P2860

P2860

Gaining mechanistic insight into coproporphyrin I as endogenous biomarker for OATP1B-mediated drug-drug interactions using population pharmacokinetic modelling and simulation.

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type

label

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932