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Structure-Guided Design and Optimization of Small Molecules Targeting the Protein–Protein Interaction between the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar AffinitiesStructural Basis for Partial Redundancy in a Class of Transcription Factors, the LIM Homeodomain Proteins, in Neural Cell Type SpecificationBiochemical and biophysical characterisation of haloalkane dehalogenases DmrA and DmrB in Mycobacterium strain JS60 and their role in growth on haloalkanesPotent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibitionSolution structure of the LIM-homeodomain transcription factor complex Lhx3/Ldb1 and the effects of a pituitary mutation on key Lhx3 interactionsSerendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases.Structural basis of PROTAC cooperative recognition for selective protein degradationCrystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.Crystallization and diffraction of an Lhx4-Isl2 complex.Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-3-Fluoro-4-hydroxyprolines: Synthesis, Conformational Analysis, and Stereoselective Recognition by the VHL E3 Ubiquitin Ligase for Targeted Protein Degradation
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Morgan S Gadd
@ast
Morgan S Gadd
@en
Morgan S Gadd
@es
Morgan S Gadd
@nl
Morgan S Gadd
@sl
type
label
Morgan S Gadd
@ast
Morgan S Gadd
@en
Morgan S Gadd
@es
Morgan S Gadd
@nl
Morgan S Gadd
@sl
prefLabel
Morgan S Gadd
@ast
Morgan S Gadd
@en
Morgan S Gadd
@es
Morgan S Gadd
@nl
Morgan S Gadd
@sl
P106
P31
P496
0000-0001-6124-0858
P569
2000-01-01T00:00:00Z