Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity.

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Cyclic Opioid Peptides.Redoubling the ring size of an endomorphin-2 analog transforms a centrally acting mu-opioid receptor agonist into a pure peripheral analgesic.Endomorphin-1 analogs containing α-methyl-β-amino acids exhibit potent analgesic activity after peripheral administration.

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P2860

Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity.

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http://www.wikidata.org/entity/Q47388982

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2015 nî lūn-bûn

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2015年学术文章

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Ring size in cyclic endomorphi ...... ding affinity and selectivity.

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Ring size in cyclic endomorphi ...... ding affinity and selectivity.

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Item

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Ring size in cyclic endomorphi ...... ding affinity and selectivity.

@en

Ring size in cyclic endomorphi ...... ding affinity and selectivity.

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Ring size in cyclic endomorphi ...... ding affinity and selectivity.

@en

Ring size in cyclic endomorphi ...... ding affinity and selectivity.

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P1476

Ring size in cyclic endomorphi ...... nding affinity and selectivity

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P2093

Anna Janecka

http://www.w3.org/2001/XMLSchema#string

Csaba Tomböly

http://www.w3.org/2001/XMLSchema#string

Girolamo Calo'

http://www.w3.org/2001/XMLSchema#string

Justyna Piekielna

http://www.w3.org/2001/XMLSchema#string

Krzysztof Łapiński

http://www.w3.org/2001/XMLSchema#string

Luca Gentilucci

http://www.w3.org/2001/XMLSchema#string

Maria Camilla Cerlesi

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P2860

Comparison of simple potential functions for simulating liquid water

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

Conformationally homogeneous cyclic tetrapeptides: useful new three-dimensional scaffolds.

Beta2-amino acids in the design of conformationally homogeneous cyclo-peptide scaffolds.

Synthesis and evaluation of the affinity toward mu-opioid receptors of atypical, lipophilic ligands based on the sequence c[-Tyr-Pro-Trp-Phe-Gly-].

Investigation of the interaction between the atypical agonist c[YpwFG] and MOR.

Pain inhibition by endomorphins.

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha.

A potent and selective endogenous agonist for the mu-opiate receptor.

The endomorphin system and its evolving neurophysiological role.

P304

6039-6046

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P31

scholarly article

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10.1039/C5OB00565E

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http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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Alicja Kluczyk

Tomasz Janecki

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2015-06-01T00:00:00Z

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P698

25948019

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Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity.

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P2860

P2860

Ring size in cyclic endomorphin-2 analogs modulates receptor binding affinity and selectivity.

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P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P50

P577

P698