Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase.

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Design, synthesis and biological activity of N4-phenylsubstituted-7H-pyrrolo[2,3-d]pyrimidin-4-amines as dual inhibitors of aurora kinase A and epidermal growth factor receptor kinase.

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2018 nî lūn-bûn

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2018年の論文

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2018年学术文章

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2018年学术文章

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2018年学术文章

@zh-cn

2018年学术文章

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2018年学术文章

@zh-my

2018年学术文章

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2018年學術文章

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2018年學術文章

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name

Design, synthesis and biologic ...... growth factor receptor kinase.

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Design, synthesis and biologic ...... growth factor receptor kinase.

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label

Design, synthesis and biologic ...... growth factor receptor kinase.

@en

Design, synthesis and biologic ...... growth factor receptor kinase.

@nl

prefLabel

Design, synthesis and biologic ...... growth factor receptor kinase.

@en

Design, synthesis and biologic ...... growth factor receptor kinase.

@nl

P1476

Design, synthesis and biologic ...... growth factor receptor kinase.

@en

P2093

Alexander Hoellein

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Anthony Fanizza

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Bradley McAllister

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Dan Stanford

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Jolanta Slawska

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Pavlina Liskova

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Sonali Kurup

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Trusha Mistry

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Ulrich Keller

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P2860

Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutan

Structure-based design of 2,6,7-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines as Aurora kinases inhibitors

Aurora isoform selectivity: design and synthesis of imidazo[4,5-b]pyridine derivatives as highly selective inhibitors of Aurora-A kinase in cells.

Design and synthesis of novel pyrimido[4,5-b]azepine derivatives as HER2/EGFR dual inhibitors

A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells

Aurora kinases in head and neck cancer

A small molecule-kinase interaction map for clinical kinase inhibitors

The quest to overcome resistance to EGFR-targeted therapies in cancer.

Synthesis and biological activity of N(4)-phenylsubstituted-6-(2,4-dichloro phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamines as vascular endothelial growth factor receptor-2 inhibitors and antiangiogenic and antitumor agents.

Targeting the cancer kinome through polypharmacology.

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74-84

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scholarly article

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10.1080/14756366.2017.1376666

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P433

http://www.w3.org/2001/XMLSchema#string

P478

http://www.w3.org/2001/XMLSchema#string

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2018-12-01T00:00:00Z

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29115879

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6009956

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