about
Retroviral intasome assembly and inhibition of DNA strand transferFunctional and structural characterization of the integrase from the prototype foamy virusA Novel Co-Crystal Structure Affords the Design of Gain-of-Function Lentiviral Integrase Mutants in the Presence of Modified PSIP1/LEDGF/p75Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and AutoregulationCrystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protectionDe novo GTP Biosynthesis Is Critical for Virulence of the Fungal Pathogen Cryptococcus neoformansA Molecular Mechanism for Bacterial Susceptibility to ZincStructural basis for the molecular recognition of polyadenosine RNA by Nab2 Zn fingersMechanism of Bacterial Interference with TLR4 Signaling by Brucella Toll/Interleukin-1 Receptor Domain-containing Protein TcpBStructural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA exportStructural basis for Pan3 binding to Pan2 and its function in mRNA recruitment and deadenylationDistinct modes of recruitment of the CCR4-NOT complex by Drosophila and vertebrate NanosStructure of the Dcp2-Dcp1 mRNA-decapping complex in the activated conformationImproved molecular replacement by density- and energy-guided protein structure optimizationVPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteinsDomain organization within the nuclear export factor Mex67:Mtr2 generates an extended mRNA binding surfaceTargeting protein-protein interactions and fragment-based drug discovery.Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus.Crystallization, X-ray diffraction analysis and preliminary structure determination of the TIR domain from the flax resistance protein L6.Stability of the octameric structure affects plasminogen-binding capacity of streptococcal enolaseSelective Targeting of the TPX2 Site of Importin-α Using Fragment-Based Ligand Design.Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB.GIGYF1/2 proteins use auxiliary sequences to selectively bind to 4EHP and repress target mRNA expression.Mille viae in eukaryotic mRNA decapping.Crystallization and X-ray diffraction analysis of the C-terminal domain of the flax rust effector protein AvrM.Structural characterization of the principal mRNA-export factor Mex67-Mtr2 from Chaetomium thermophilum.Structural Characterization of the Chaetomium thermophilum TREX-2 Complex and its Interaction with the mRNA Nuclear Export Factor Mex67:Mtr2.Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling.1.25 Å resolution structure of an RNA 20-mer that binds to the TREX2 complex.The principal mRNA nuclear export factor NXF1:NXT1 forms a symmetric binding platform that facilitates export of retroviral CTE-RNAStructural and Mechanistic Analysis of the Choline Sulfatase from Sinorhizobium melliloti: A Class I Sulfatase Specific for an Alkyl Sulfate Ester.The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.Structural and biochemical analysis of a NOT1 MIF4G-like domain of the CCR4-NOT complexStructural basis for the assembly and disassembly of mRNA nuclear export complexesStructural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeastReconstitution of recombinant human CCR4-NOT reveals molecular insights into regulated deadenylationA low-complexity region in human XRN1 directly recruits deadenylation and decapping factors in 5'-3' messenger RNA decayUnique repression domains of Pumilio utilize deadenylation and decapping factors to accelerate destruction of target mRNAs
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Eugene Valkov
@ast
Eugene Valkov
@en
Eugene Valkov
@es
Eugene Valkov
@nl
Eugene Valkov
@sl
type
label
Eugene Valkov
@ast
Eugene Valkov
@en
Eugene Valkov
@es
Eugene Valkov
@nl
Eugene Valkov
@sl
prefLabel
Eugene Valkov
@ast
Eugene Valkov
@en
Eugene Valkov
@es
Eugene Valkov
@nl
Eugene Valkov
@sl
P106
P21
P31
P496
0000-0002-3721-1739