Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

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Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes.mTORC1 and Nutrient Homeostasis: The Central Role of the Lysosome.Crosstalk between the Warburg effect, redox regulation and autophagy induction in tumourigenesis.

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P2860

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

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Intersubunit Crosstalk in the ...... ly to Amino Acid Availability.

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Intersubunit Crosstalk in the ...... ly to Amino Acid Availability.

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Item

label

Intersubunit Crosstalk in the ...... ly to Amino Acid Availability.

@en

Intersubunit Crosstalk in the ...... ly to Amino Acid Availability.

@nl

prefLabel

Intersubunit Crosstalk in the ...... ly to Amino Acid Availability.

@en

Intersubunit Crosstalk in the ...... ly to Amino Acid Availability.

@nl

P1476

Intersubunit Crosstalk in the ...... ly to Amino Acid Availability.

@en

P2093

Abigail Choe

http://www.w3.org/2001/XMLSchema#string

David M Sabatini

http://www.w3.org/2001/XMLSchema#string

Kuang Shen

http://www.w3.org/2001/XMLSchema#string

P2860

A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1

Cloning of a novel family of mammalian GTP-binding proteins (RagA, RagBs, RagB1) with remote similarity to the Ras-related GTPases

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

Discovery of new Longin and Roadblock domains that form platforms for small GTPases in Ragulator and TRAPP-II

P304

552-565.e8

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P31

scholarly article

P356

10.1016/J.MOLCEL.2017.09.026

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P433

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P478

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2017-10-17T00:00:00Z

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29056322

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P932

5674802

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Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

about

P2860

P2860

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability.

description

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type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P433

P478

P577

P698

P932