Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.
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The VHL tumor suppressor: master regulator of HIFIdentification of an alternative mechanism of degradation of the hypoxia-inducible factor-1alphaRegulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levelsHIF-1α and growth plate development: what we really knowThe multifaceted role of the vasculature in endochondral fracture repairHypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau proteinVhlh gene deletion induces Hif-1-mediated cell death in thymocytesFlavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage RepairAngiogenesis in bone regeneration.Deciphering von Hippel-Lindau (VHL/Vhl)-associated pancreatic manifestations by inactivating Vhl in specific pancreatic cell populations.A central role for hypoxic signaling in cartilage, bone, and hematopoiesis.VHL deletion impairs mammary alveologenesis but is not sufficient for mammary tumorigenesis.Decreased growth of Vhl-/- fibrosarcomas is associated with elevated levels of cyclin kinase inhibitors p21 and p27.Analysis of Mouse Growth Plate Development.Inactivation of Vhl in osteochondral progenitor cells causes high bone mass phenotype and protects against age-related bone loss in adult mice.Loss of Vhl in cartilage accelerated the progression of age-associated and surgically induced murine osteoarthritisHypoxia inhibits hypertrophic differentiation and endochondral ossification in explanted tibiae.Smad7 regulates terminal maturation of chondrocytes in the growth plateMutant IDH is sufficient to initiate enchondromatosis in mice.HIF targets in bone remodeling and metastatic disease.The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.Metabolic consideration of epiphyseal growth: survival responses in a taxing environmentComplex cellular functions of the von Hippel-Lindau tumor suppressor gene: insights from model organisms.Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.Von Hippel-Lindau disease (VHL): a need for a murine model with retinal hemangioblastomaThe VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting.Hypoxia-inducible factor-1 (HIF-1) but not HIF-2 is essential for hypoxic induction of collagen prolyl 4-hydroxylases in primary newborn mouse epiphyseal growth plate chondrocytes.Hypoxia and HIF-1alpha in chondrogenesis.In vivo targeted deletion of calpain small subunit, Capn4, in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formationKnockdown of von Hippel-Lindau protein decreases lung cancer cell proliferation and colonization.HIF-1: an age-dependent regulator of lens cell proliferation.Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee jointsThe VHL tumor suppressor and HIF: insights from genetic studies in miceSuppression of von Hippel-Lindau Protein in Fibroblasts Protects against Bleomycin-Induced Pulmonary Fibrosis.A novel transgenic mouse model of growth plate dysplasia reveals that decreased chondrocyte proliferation due to chronic ER stress is a key factor in reduced bone growth.Oxygen in health and disease: regulation of oxygen homeostasis--clinical implications.Exposure to Excess Phenobarbital Negatively Influences the Osteogenesis of Chick EmbryosHypoxia. HIF-mediated articular chondrocyte function: prospects for cartilage repair.Role of hypoxia-inducible factor-1alpha in angiogenic-osteogenic coupling.Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF
P2860
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P2860
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh-hant
name
Deletion of Vhlh in chondrocyt ...... ring growth plate development.
@en
Deletion of Vhlh in chondrocyt ...... ring growth plate development.
@nl
type
label
Deletion of Vhlh in chondrocyt ...... ring growth plate development.
@en
Deletion of Vhlh in chondrocyt ...... ring growth plate development.
@nl
prefLabel
Deletion of Vhlh in chondrocyt ...... ring growth plate development.
@en
Deletion of Vhlh in chondrocyt ...... ring growth plate development.
@nl
P2093
P50
P356
P1433
P1476
Deletion of Vhlh in chondrocyt ...... uring growth plate development
@en
P2093
Amato J Giaccia
Bjorn R Olsen
David Pfander
Denise A Chan
Elazar Zelzer
Ernestina Schipani
Melissa C Knight
P304
P356
10.1242/DEV.01138
P407
P577
2004-05-01T00:00:00Z