A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

@en

A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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P1476

A Dynamic Mathematical Model of Bile Acid Clearance in HepaRG Cells.

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P2093

Ahmad Sharanek

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André Guillouzo

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Daniel Kaschek

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Jens Timmer

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Richard J Weaver

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P2860

Bile acids: regulation of synthesis

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs.

Mechanistic pharmacokinetic modeling for the prediction of transporter-mediated disposition in humans from sandwich culture human hepatocyte data.

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood.

Sandwich-cultured hepatocytes: an in vitro model to evaluate hepatobiliary transporter-based drug interactions and hepatotoxicity.

An updated review on drug-induced cholestasis: mechanisms and investigation of physicochemical properties and pharmacokinetic parameters.

Species differences in hepatobiliary disposition of taurocholic acid in human and rat sandwich-cultured hepatocytes: implications for drug-induced liver injury

Systems pharmacology modeling predicts delayed presentation and species differences in bile acid-mediated troglitazone hepatotoxicity

Motility of bile canaliculi in the living animal: implications for bile flow.

Hepatobiliary transporters and drug-induced cholestasis.

P304

48-57

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P31

scholarly article

P356

10.1093/TOXSCI/KFX199

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P433

http://www.w3.org/2001/XMLSchema#string

P478

161

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P577

2017-09-18T00:00:00Z

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P698

29029322

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