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The Proapoptotic G41S Mutation to Human Cytochrome c Alters the Heme Electronic Structure and Increases the Electron Self-Exchange RateA novel Bcl-2-like inhibitor of apoptosis is encoded by the parapoxvirus ORF virusA mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia.Congenital thrombocytopenia and cytochrome C mutation: a matter of birth and death.Interspecies Variation in the Functional Consequences of Mutation of Cytochrome cMegakaryocytes from CYCS mutation-associated thrombocytopenia release platelets by both proplatelet-dependent and -independent processes.Targeting the apoptosome for cancer therapy.The role of peroxiredoxin 1 in redox sensing and transducing.Conformational change and human cytochrome c function: mutation of residue 41 modulates caspase activation and destabilizes Met-80 coordination.Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells.The orf virus inhibitor of apoptosis functions in a Bcl-2-like manner, binding and neutralizing a set of BH3-only proteins and active Bax.Mitochondria-targeted antioxidants do not prevent tumour necrosis factor-induced necrosis of L929 cells.Tumor necrosis factor induces distinct patterns of caspase activation in WEHI-164 cells associated with apoptosis or necrosis depending on cell cycle stage.Tumor necrosis factor-induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy-changes that can be mediated by TNFR-I or TNFR-II.Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.Endoproteolytic processing of recombinant proalbumin variants by the yeast Kex2 protease.Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis: evidence from mitochondria-targeted antioxidants.Oxidation of mitochondrial peroxiredoxin 3 during the initiation of receptor-mediated apoptosis.Differentiation and cell density upregulate cytochrome c levels in megakaryoblastic cell lines: Implications for analysis of CYCS-associated thrombocytopenia.Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.The proportion of Met80-sulfoxide dictates peroxidase activity of human cytochrome cEnhancing the peroxidase activity of cytochromecby mutation of residue 41: implications for the peroxidase mechanism and cytochromecreleaseRapid uptake of lipophilic triphenylphosphonium cations by mitochondria in vivo following intravenous injection: Implications for mitochondria-specific therapies and probesChanges in mitochondrial membrane potential during staurosporine-induced apoptosis in Jurkat cellsThe Imprinted Gene Peg3 Is Not Essential for Tumor Necrosis Factor α SignalingThe predicted proteinase furin is not the hepatic proalbumin convertaseCYCS gene variants associated with thrombocytopenia
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description
hulumtuese
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Elizabeth C. Ledgerwood
@ast
Elizabeth C. Ledgerwood
@en
Elizabeth C. Ledgerwood
@es
Elizabeth C. Ledgerwood
@nl
Elizabeth C. Ledgerwood
@sl
type
label
Elizabeth C. Ledgerwood
@ast
Elizabeth C. Ledgerwood
@en
Elizabeth C. Ledgerwood
@es
Elizabeth C. Ledgerwood
@nl
Elizabeth C. Ledgerwood
@sl
prefLabel
Elizabeth C. Ledgerwood
@ast
Elizabeth C. Ledgerwood
@en
Elizabeth C. Ledgerwood
@es
Elizabeth C. Ledgerwood
@nl
Elizabeth C. Ledgerwood
@sl
P106
P1153
6701685710
P21
P31
P496
0000-0002-4956-6043