Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.

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Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.Structural insights into the gating of DNA passage by the topoisomerase II DNA-gate

P2860

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Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.

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http://www.wikidata.org/entity/Q47699480

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年學術文章

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Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt

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Producing irreversible topoiso ...... ionine coordination chemistry.

@en

type

Item

label

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt

@nl

Producing irreversible topoiso ...... ionine coordination chemistry.

@en

prefLabel

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt

@nl

Producing irreversible topoiso ...... ionine coordination chemistry.

@en

P1476

Producing irreversible topoiso ...... ionine coordination chemistry.

@en

P2093

Ko-Ting Liu

http://www.w3.org/2001/XMLSchema#string

Shin-Fu Chen

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Te-Sheng Lin

http://www.w3.org/2001/XMLSchema#string

Tsai-Kun Li

http://www.w3.org/2001/XMLSchema#string

Yi-Song Chen

http://www.w3.org/2001/XMLSchema#string

Yi-Wen Liao

http://www.w3.org/2001/XMLSchema#string

Ying-Ren Wang

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Targeting DNA topoisomerase II in cancer chemotherapy

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Processing of X-ray diffraction data collected in oscillation mode

Drugging topoisomerases: lessons and challenges

Structures of Lung Cancer-Derived EGFR Mutants and Inhibitor Complexes: Mechanism of Activation and Insights into Differential Inhibitor Sensitivity

Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases

Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide

The Structure of DNA-Bound Human Topoisomerase II Alpha: Conformational Mechanisms for Coordinating Inter-Subunit Interactions with DNA Cleavage

On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

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scholarly article

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10.1093/NAR/GKX742

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English

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Tun-Cheng Chien

Chyuan-Chuan Wu

Nei-Li Chan

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2017-08-24T00:00:00Z

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28977631

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5737487

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Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.

about

P2860

P2860

Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry.

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type

label

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P932