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Synthesis of combretastatin A-4 O-alkyl derivatives and evaluation of their cytotoxic, antiangiogenic and antitelomerase activity.Synthesis and biological evaluation of truncated α-tubulin-binding pironetin analogues lacking alkyl pendants in the side chain or the dihydropyrone ring.Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B.Inhibitory effect of pironetin analogue/colchicine hybrids on the expression of the VEGF, hTERT and c-Myc genes.Double diastereoselection in aldol reactions mediated by dicyclohexylchloroborane between L-erythrulose derivatives and chiral aldehydes. The Felkin-Anh versus Cornforth dichotomy.Aldol reactions between L-erythrulose derivatives and chiral alpha-amino and alpha-fluoro aldehydes: competition between Felkin-Anh and Cornforth transition states.Double diastereoselection in aldol reactions mediated by dicyclohexylchloroborane between chiral aldehydes and a chiral ethyl ketone derived from L-erythrulose. synthesis of a C1-C9 fragment of the structure of the antifungal metabolite soraphen A1aEmergent Catalytic Behavior of Self-Assembled Low Molecular Weight Peptide-Based Aggregates and Hydrogels.Triazolyl-Based Molecular Gels as Ligands for Autocatalytic 'Click' Reactions.Synthesis, spectroscopic studies and biological evaluation of acridine derivatives: The role of aggregation on the photodynamic efficiency.The Mechanism of the Interactions of Pironetin Analog/Combretastatin A-4 Hybrids with Tubulin.Tandem Catalysis of an Aldol-‘Click’ Reaction System within a Molecular HydrogelStudy of the effect of polymorphism on the self-assembly and catalytic performance of an l-proline based molecular hydrogelatorFreezing Capture of Polymorphic Aggregates of BolaamphiphilicL-Valine-Based Molecular HydrogelatorsStereoselective synthesis and structural correction of the naturally occurring lactone stagonolide GStereoselective synthesis of the cytotoxic 14-membered macrolide aspergillide ADouble diastereoselection in anti aldol reactions mediated by dicyclohexylchloroborane between an L-erythrulose derivative and chiral aldehydesDesign and synthesis of pironetin analogue/combretastatin A-4 hybrids containing a 1,2,3-triazole ring and evaluation of their cytotoxic activityDesign and synthesis of pironetin analogue/colchicine hybrids and study of their cytotoxic activity and mechanisms of interaction with tubulin
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Santiago Díaz-Oltra
@ast
Santiago Díaz-Oltra
@en
Santiago Díaz-Oltra
@es
Santiago Díaz-Oltra
@nl
Santiago Díaz-Oltra
@sl
type
label
Santiago Díaz-Oltra
@ast
Santiago Díaz-Oltra
@en
Santiago Díaz-Oltra
@es
Santiago Díaz-Oltra
@nl
Santiago Díaz-Oltra
@sl
prefLabel
Santiago Díaz-Oltra
@ast
Santiago Díaz-Oltra
@en
Santiago Díaz-Oltra
@es
Santiago Díaz-Oltra
@nl
Santiago Díaz-Oltra
@sl
P1053
B-8355-2009
P106
P1950
P21
P31
P3829
P496
0000-0002-4771-5885