p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

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Dysregulation of Neuronal Iron Homeostasis as an Alternative Unifying Effect of Mutations Causing Familial Alzheimer's Disease

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Q58785711-A3BF9205-5885-45C2-8440-CB23ED8892B9

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p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

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http://www.wikidata.org/entity/Q47860140

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2017 nî lūn-bûn

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2017年の論文

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2017年学术文章

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2017年学术文章

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2017年学术文章

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2017年学术文章

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@zh-sg

2017年學術文章

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2017年學術文章

@zh-hant

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p75 neurotrophin receptor inte ...... s aggravating amyloidogenesis.

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p75 neurotrophin receptor inte ...... s aggravating amyloidogenesis.

@nl

type

Item

label

p75 neurotrophin receptor inte ...... s aggravating amyloidogenesis.

@en

p75 neurotrophin receptor inte ...... s aggravating amyloidogenesis.

@nl

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p75 neurotrophin receptor inte ...... s aggravating amyloidogenesis.

@en

p75 neurotrophin receptor inte ...... s aggravating amyloidogenesis.

@nl

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p75 neurotrophin receptor inte ...... es aggravating amyloidogenesis

@en

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Hong Liao

http://www.w3.org/2001/XMLSchema#string

Jin-Hua Zhong

http://www.w3.org/2001/XMLSchema#string

Kevin S Smith

http://www.w3.org/2001/XMLSchema#string

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The Amyloid Precursor Protein is rapidly transported from the Golgi apparatus to the lysosome and where it is processed into beta-amyloid.

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

Amyloid beta binds trimers as well as monomers of the 75-kDa neurotrophin receptor and activates receptor signaling

Sortilin is essential for proNGF-induced neuronal cell death

The role of APP and BACE1 trafficking in APP processing and amyloid-β generation

Regulation of cell survival by secreted proneurotrophins.

Cleavage of p75 neurotrophin receptor by alpha-secretase and gamma-secretase requires specific receptor domains.

Neurotrophins Redirect p75NTR from a clathrin-independent to a clathrin-dependent endocytic pathway coupled to axonal transport

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302-317

http://www.w3.org/2001/XMLSchema#string

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scholarly article

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10.1111/JNC.14206

http://www.w3.org/2001/XMLSchema#string

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English

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http://www.w3.org/2001/XMLSchema#string

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144

http://www.w3.org/2001/XMLSchema#string

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Moses V Chao

Larisa Bobrovskaya

Xin-Fu Zhou

Noralyn B Mañucat-Tan

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2017-09-27T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

28869759

http://www.w3.org/2001/XMLSchema#string

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

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P2860

P2860

p75 neurotrophin receptor interacts with and promotes BACE1 localization in endosomes aggravating amyloidogenesis.

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698