Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A.
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Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSAAnalysis of IgG with specificity for variant surface antigens expressed by placental Plasmodium falciparum isolatesAntibodies from malaria-exposed pregnant women recognize trypsin resistant epitopes on the surface of Plasmodium falciparum-infected erythrocytes selected for adhesion to chondroitin sulphate ACellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and paritySub-grouping of Plasmodium falciparum 3D7 var genes based on sequence analysis of coding and non-coding regionsMaternal malaria and gravidity interact to modify infant susceptibility to malaria.The Influence of Sub-Unit Composition and Expression System on the Functional Antibody Response in the Development of a VAR2CSA Based Plasmodium falciparum Placental Malaria VaccineThe Structure of a Chondroitin Sulfate-binding Domain Important in Placental MalariaStructural Comparison of Two CSPG-Binding DBL Domains from the VAR2CSA Protein Important in Malaria during PregnancyVar2CSA minimal CSA binding region is located within the N-terminal regionSkeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surfaceAntigen reversal identifies targets of opsonizing IgGs against pregnancy-associated malariaDissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cellsHIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites.Disruption of var2csa gene impairs placental malaria associated adhesion phenotype.Structural insight into epitopes in the pregnancy-associated malaria protein VAR2CSAPlasmodium falciparum transcriptome analysis reveals pregnancy malaria associated gene expression.Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSAAn upstream open reading frame controls translation of var2csa, a gene implicated in placental malaria.Differential recognition of P. falciparum VAR2CSA domains by naturally acquired antibodies in pregnant women from a malaria endemic area.IgG isotypic antibodies to crude Plasmodium falciparum blood-stage antigen associated with placental malaria infection in parturient Cameroonian womenTowards the rational design of a candidate vaccine against pregnancy associated malaria: conserved sequences of the DBL6epsilon domain of VAR2CSA.Strain-transcendent immune response to recombinant Var2CSA DBL5-ε domain block P. falciparum adhesion to placenta-derived BeWo cells under flow conditions.Dynamics in the cytoadherence phenotypes of Plasmodium falciparum infected erythrocytes isolated during pregnancy.Effect of IPTp on Plasmodium falciparum antibody levels among pregnant women and their babies in a sub-urban coastal area in GhanaDecrease in Numbers of Naive and Resting B Cells in HIV-Infected Kenyan Adults Leads to a Proportional Increase in Total and Plasmodium falciparum-Specific Atypical Memory B Cells.Rapid acquisition of isolate-specific antibodies to chondroitin sulfate A-adherent plasmodium falciparum isolates in Ghanaian primigravidae.Cross-reactive surface epitopes on chondroitin sulfate A-adherent Plasmodium falciparum-infected erythrocytes are associated with transcription of var2csa.Immunohistological characterization of macrophage migration inhibitory factor expression in Plasmodium falciparum-infected placentas.Histopathologies, immunolocalization, and a glycan binding screen provide insights into Plasmodium falciparum interactions with the human placenta.Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.Immunization with VAR2CSA-DBL5 recombinant protein elicits broadly cross-reactive antibodies to placental Plasmodium falciparum-infected erythrocytes.The kinetics of antibody binding to Plasmodium falciparum VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs.The role of Plasmodium falciparum var genes in malaria in pregnancy.A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern.Effects of pregnancy and intensity of Plasmodium falciparum transmission on immunoglobulin G subclass responses to variant surface antigens.Antibodies to variant antigens on the surfaces of infected erythrocytes are associated with protection from malaria in Ghanaian children.Gravidity-dependent production of antibodies that inhibit binding of Plasmodium falciparum-infected erythrocytes to placental chondroitin sulfate proteoglycan during pregnancyPlacental malaria induces variant-specific antibodies of the cytophilic subtypes immunoglobulin G1 (IgG1) and IgG3 that correlate with adhesion inhibitory activity.Subdomain 3 of Plasmodium falciparum VAR2CSA DBL3x is identified as a minimal chondroitin sulfate A-binding region.
P2860
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P2860
Plasma antibodies from malaria-exposed pregnant women recognize variant surface antigens on Plasmodium falciparum-infected erythrocytes in a parity-dependent manner and block parasite adhesion to chondroitin sulfate A.
description
2000 nî lūn-bûn
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2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
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2000年学术文章
@zh-hans
2000年学术文章
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name
Plasma antibodies from malaria ...... sion to chondroitin sulfate A.
@en
Plasma antibodies from malaria ...... sion to chondroitin sulfate A.
@nl
type
label
Plasma antibodies from malaria ...... sion to chondroitin sulfate A.
@en
Plasma antibodies from malaria ...... sion to chondroitin sulfate A.
@nl
prefLabel
Plasma antibodies from malaria ...... sion to chondroitin sulfate A.
@en
Plasma antibodies from malaria ...... sion to chondroitin sulfate A.
@nl
P2093
P921
P1476
Plasma antibodies from malaria ...... sion to chondroitin sulfate A.
@en
P2093
Akanmori BD
Staalsoe T
Theander TG
P304
P356
10.4049/JIMMUNOL.165.6.3309
P407
P577
2000-09-01T00:00:00Z