Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions.
about
Catalytically active membrane-distal phosphatase domain of receptor protein-tyrosine phosphatase alpha is required for Src activationSubdomain X of the kinase domain of Lck binds CD45 and facilitates dephosphorylationIntegrin CD11a cytoplasmic tail interacts with the CD45 membrane-proximal protein tyrosine phosphatase domain 1Receptor protein tyrosine phosphatase-receptor tyrosine kinase substrate screen identifies EphA2 as a target for LAR in cell migrationUltrasensitivity in multisite phosphorylation of membrane-anchored proteinsProtein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transductionDimerization of receptor protein-tyrosine phosphatase alpha in living cellsMining the function of protein tyrosine phosphatases in health and diseaseMultiple interactions between receptor protein-tyrosine phosphatase (RPTP) alpha and membrane-distal protein-tyrosine phosphatase domains of various RPTPsMultimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs). Inhibition of RPTPalpha enzymatic activityIntra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatasesThe MAM (meprin/A5-protein/PTPmu) domain is a homophilic binding site promoting the lateral dimerization of receptor-like protein-tyrosine phosphatase muDimerization inhibits the activity of receptor-like protein-tyrosine phosphatase-alphaDimerization in vivo and inhibition of the nonreceptor form of protein tyrosine phosphatase epsilonGain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alphaPhosphorylation of CD45 by casein kinase 2. Modulation of activity and mutational analysis.Genomic organization of the channel catfish CD45 functional gene and CD45 pseudogenesReceptor-like protein tyrosine phosphatase alpha homodimerizes on the cell surface.CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cellsCD45: all is not yet crystal clear.Structural basis for the function and regulation of the receptor protein tyrosine phosphatase CD45Differential impact of the CD45 juxtamembrane wedge on central and peripheral T cell receptor responses.Identification of receptor protein tyrosine phosphatases (RPTPs) as regulators of receptor tyrosine kinases (RTKs) using an RPTP siRNA-RTK substrate screen.Regulation of receptor protein-tyrosine phosphatase alpha by oxidative stress.Differential function of PTPalpha and PTPalpha Y789F in T cells and regulation of PTPalpha phosphorylation at Tyr-789 by CD45.Antibody-induced dimerization of HARPTPalpha-EGFR chimera suggests a ligand dependent mechanism of regulation for RPTPalpha.Suramin derivatives as inhibitors and activators of protein-tyrosine phosphatases.CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase.Expression of CD45 lacking the catalytic protein tyrosine phosphatase domain modulates Lck phosphorylation and T cell activation.Regulatory Mechanisms and Novel Therapeutic Targeting Strategies for Protein Tyrosine Phosphatases.
P2860
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P2860
Characterization of recombinant CD45 cytoplasmic domain proteins. Evidence for intramolecular and intermolecular interactions.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Characterization of recombinan ...... d intermolecular interactions.
@en
Characterization of recombinan ...... d intermolecular interactions.
@nl
type
label
Characterization of recombinan ...... d intermolecular interactions.
@en
Characterization of recombinan ...... d intermolecular interactions.
@nl
prefLabel
Characterization of recombinan ...... d intermolecular interactions.
@en
Characterization of recombinan ...... d intermolecular interactions.
@nl
P2860
P356
P1476
Characterization of recombinan ...... d intermolecular interactions.
@en
P2093
P2860
P304
17839-17845
P356
10.1074/JBC.273.28.17839
P407
P577
1998-07-01T00:00:00Z