A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
about
Central tolerance: learning self-control in the thymusThe timing of TCR alpha expression critically influences T cell development and selectionProtein kinase C-η controls CTLA-4-mediated regulatory T cell function.Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses.The role of the thymus in tolerance.Central tolerance: what have we learned from mice?Histone deacetylase 7 functions as a key regulator of genes involved in both positive and negative selection of thymocytesClonal deletion and the fate of autoreactive thymocytes that survive negative selection.The B7/CD28 costimulatory family in autoimmunity.Deletion of CTLA-4 on regulatory T cells during adulthood leads to resistance to autoimmunity.CTLA-4 controls the thymic development of both conventional and regulatory T cells through modulation of the TCR repertoire.Requirements for selection of conventional and innate T lymphocyte lineages.Induction of autoimmune disease by deletion of CTLA-4 in mice in adulthood.Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.Enhanced selection of FoxP3+ T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease.Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell developmentGenetic control of thymic development of CD4+CD25+FoxP3+ regulatory T lymphocytes.Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling.Molecular and genetic parameters defining T-cell clonal selection.Regulatory T-cell differentiation versus clonal deletion of autoreactive thymocytes.Immune tolerance and transplantation.Signals and pathways controlling regulatory T cells.Characterization of MHC class-I restricted TCRalphabeta+ CD4- CD8- double negative T cells recognizing the gp100 antigen from a melanoma patient after gp100 vaccination.Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.T-cell tolerance: central and peripheralThe role of CTLA-4 in immune regulation.The PTPN22gain-of-function+1858T(+) genotypes correlate with low IL-2 expression in thymomas and predispose to myasthenia gravis.CD28 T-cell costimulatory molecule expression in pemphigus vulgaris.In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection.The swinging pendulum of cancer immunotherapy personalization
P2860
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P2860
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
@en
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
@nl
type
label
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
@en
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
@nl
prefLabel
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
@en
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
@nl
P2093
P1476
A role for the B7-1/B7-2:CD28/CTLA-4 pathway during negative selection.
@en
P2093
Arlene H Sharpe
Janet E Buhlmann
Sheryl Krevsky Elkin
P304
P356
10.4049/JIMMUNOL.170.11.5421
P407
P577
2003-06-01T00:00:00Z