A detergent-insoluble membrane compartment contains A beta in vivo.
about
Identification of phospholipid scramblase 1 as a novel interacting molecule with beta -secretase (beta -site amyloid precursor protein (APP) cleaving enzyme (BACE))Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes.Molecular genetics of the caveolin gene family: implications for human cancers, diabetes, Alzheimer disease, and muscular dystrophy.A single mutation in the nonamyloidogenic region of islet amyloid polypeptide greatly reduces toxicityAmyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid raftsThe involvement of microRNAs in neurodegenerative diseasesThe Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds CholesterolAccumulation of amyloid beta-protein in the low-density membrane domain accurately reflects the extent of beta-amyloid deposition in the brainCommon binding sites for beta-amyloid fibrils and fibroblast growth factor-2 in heparan sulfate from human cerebral cortexβ-amyloid triggers ALS-associated TDP-43 pathology in AD modelsVisualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation.Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects.Glycosylphosphatidylinositol-anchor intermediates associate with triton-insoluble membranes in subcellular compartments that include the endoplasmic reticulum.Abeta42 mutants with different aggregation profiles induce distinct pathologies in DrosophilaCross-talk of membrane lipids and Alzheimer-related proteins.Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.Biology of presenilins as causative molecules for Alzheimer disease.Detergent-insoluble glycosphingolipid/cholesterol-rich membrane domains, lipid rafts and caveolae (review).Alzheimer's disease and the amyloid beta protein: What is the role of amyloid?Alpha-synuclein in Lewy body disease and Alzheimer's disease.Caveolins, liquid-ordered domains, and signal transduction.Proteolysis in Alzheimer's disease. Can plasmin tip the balance?HFE gene variants, iron, and lipids: a novel connection in Alzheimer's diseaseRoles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis.Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection.Caveolins and cellular cholesterol balance.The functions of the amyloid precursor protein gene.A plausible function of the prion protein: conjectures and a hypothesis.Identification of novel γ-secretase-associated proteins in detergent-resistant membranes from brain.A distinct subfraction of Aβ is responsible for the high-affinity Pittsburgh compound B-binding site in Alzheimer's disease brainEvidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein.Effects of human apolipoprotein E isoforms on the amyloid beta-protein concentration and lipid composition in brain low-density membrane domainsInduction of autophagy by a novel small molecule improves aβ pathology and ameliorates cognitive deficitsRegulation of tau phosphorylation and protection against beta-amyloid-induced neurodegeneration by lithium. Possible implications for Alzheimer's disease.Alzheimer's disease: beta-Amyloid protein and tau.Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.Cholesterol: from heart attacks to Alzheimer's disease.Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease.MicroRNA-137/181c regulates serine palmitoyltransferase and in turn amyloid β, novel targets in sporadic Alzheimer's disease.
P2860
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P2860
A detergent-insoluble membrane compartment contains A beta in vivo.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
A detergent-insoluble membrane compartment contains A beta in vivo.
@en
A detergent-insoluble membrane compartment contains A beta in vivo.
@nl
type
label
A detergent-insoluble membrane compartment contains A beta in vivo.
@en
A detergent-insoluble membrane compartment contains A beta in vivo.
@nl
prefLabel
A detergent-insoluble membrane compartment contains A beta in vivo.
@en
A detergent-insoluble membrane compartment contains A beta in vivo.
@nl
P2093
P356
P1433
P1476
A detergent-insoluble membrane compartment contains A beta in vivo.
@en
P2093
P2888
P304
P356
10.1038/NM0698-730
P407
P577
1998-06-01T00:00:00Z