Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
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The TspanC8 subgroup of tetraspanins interacts with A disintegrin and metalloprotease 10 (ADAM10) and regulates its maturation and cell surface expressionTspanC8 tetraspanins regulate ADAM10/Kuzbanian trafficking and promote Notch activation in flies and mammalsPromotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipidsEndocytosis of synaptic ADAM10 in neuronal plasticity and Alzheimer's diseaseTetraspanins as regulators of the tumour microenvironment: implications for metastasis and therapeutic strategies.The cytoplasmic domain of a disintegrin and metalloproteinase 10 (ADAM10) regulates its constitutive activity but is dispensable for stimulated ADAM10-dependent shedding.Serological immune response against ADAM10 pro-domain is associated with favourable prognosis in stage III colorectal cancer patientsTwo Paralogous Tetraspanins TSP-12 and TSP-14 Function with the ADAM10 Metalloprotease SUP-17 to Promote BMP Signaling in Caenorhabditis elegansPhysical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10.TspanC8 tetraspanins differentially regulate the cleavage of ADAM10 substrates, Notch activation and ADAM10 membrane compartmentalization.ADAM Proteases and Gastrointestinal Function.Tspan5 is an independent favourable prognostic factor and suppresses tumour growth in gastric cancerTetraspanins Function as Regulators of Cellular Signaling.Proteolytic processing of the prion protein in health and disease.Roles of endoproteolytic α-cleavage and shedding of the prion protein in neurodegeneration.Mapping orphan proteases by proteomics: meprin metalloproteases deciphered as potential therapeutic targets.The role of epigenetic mechanisms in Notch signaling during development.ADAM-family metalloproteinases in lung inflammation: potential therapeutic targets.TspanC8 Tetraspanins and A Disintegrin and Metalloprotease 10 (ADAM10) Interact via Their Extracellular Regions: EVIDENCE FOR DISTINCT BINDING MECHANISMS FOR DIFFERENT TspanC8 PROTEINS.New insights into the tetraspanin Tspan5 using novel monoclonal antibodies.The Emerging Role of Tetraspanins in the Proteolytic Processing of the Amyloid Precursor Protein.Regulation of A disintegrin and metalloproteinase (ADAM) family sheddases ADAM10 and ADAM17: The emerging role of tetraspanins and rhomboids.A mutation in the human tetraspanin CD81 gene is expressed as a truncated protein but does not enable CD19 maturation and cell surface expression.Effect of A disintegrin and metalloproteinase 10 gene silencing on the proliferation, invasion and migration of the human tongue squamous cell carcinoma cell line TCA8113.The Metalloprotease Meprin β Is an Alternative β-Secretase of APP.Scissor sisters: regulation of ADAM10 by the TspanC8 tetraspanins.ADAM10-Interacting Tetraspanins Tspan5 and Tspan17 Regulate VE-Cadherin Expression and Promote T Lymphocyte Transmigration.Proteases at work: cues for understanding neural development and degeneration.Identification of co-expressed gene signatures in mouse B1, marginal zone and B2 B-cell populations.TSPAN15 interacts with BTRC to promote oesophageal squamous cell carcinoma metastasis via activating NF-κB signaling.Regulation of Leukocytes by TspanC8 Tetraspanins and the "Molecular Scissor" ADAM10.
P2860
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P2860
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh-hant
name
Tetraspanin15 regulates cellul ...... he ectodomain sheddase ADAM10.
@en
Tetraspanin15 regulates cellul ...... he ectodomain sheddase ADAM10.
@nl
type
label
Tetraspanin15 regulates cellul ...... he ectodomain sheddase ADAM10.
@en
Tetraspanin15 regulates cellul ...... he ectodomain sheddase ADAM10.
@nl
prefLabel
Tetraspanin15 regulates cellul ...... he ectodomain sheddase ADAM10.
@en
Tetraspanin15 regulates cellul ...... he ectodomain sheddase ADAM10.
@nl
P2093
P1476
Tetraspanin15 regulates cellul ...... he ectodomain sheddase ADAM10.
@en
P2093
Dirk Schmidt-Arras
Johannes Prox
Michael Willenbrock
Paul Saftig
Silvio Weber
Tobias Lehmann
P2888
P304
P356
10.1007/S00018-012-0960-2
P577
2012-03-25T00:00:00Z