3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.
about
The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetasesHerbimycins D-F, ansamycin analogues from Streptomyces sp. RM-7-15Combinatorial biosynthesis--potential and problems.Insights into the biosynthesis of the benzoquinone ansamycins geldanamycin and herbimycin, obtained by gene sequencing and disruption.Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C.Identification of the varR gene as a transcriptional regulator of virginiamycin S resistance in Streptomyces virginiaeMicrobial origin of plant-type 2-keto-3-deoxy-D-arabino-heptulosonate 7-phosphate synthases, exemplified by the chorismate- and tryptophan-regulated enzyme from Xanthomonas campestris.The interplay between mutasynthesis and semisynthesis: generation and evaluation of an ansamitocin library.Biosynthesis of 3,5-AHBA-derived natural products.A comparative analysis of the sugar phosphate cyclase superfamily involved in primary and secondary metabolismBiosynthetic gene cluster of cetoniacytone A, an unusual aminocyclitol from the endosymbiotic Bacterium Actinomyces sp. Lu 9419.Streptomyces genetics: a genomic perspective.Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.Microdiversity and evidence for high dispersal rates in the marine actinomycete 'Salinispora pacifica'Broad substrate specificity of the amide synthase in S. hygroscopicus--new 20-membered macrolactones derived from geldanamycin.Engineered biosynthesis of an ansamycin polyketide precursor in Escherichia coli.Combinatorial biosynthesis of reduced polyketides.Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches.The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review.Progress in Understanding the Genetic Information and Biosynthetic Pathways behind Amycolatopsis Antibiotics, with Implications for the Continued Discovery of Novel Drugs.Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemobiosynthetic approach.Hierarchical amino acid utilization and its influence on fermentation dynamics: rifamycin B fermentation using Amycolatopsis mediterranei S699, a case study.Modification of rifamycin polyketide backbone leads to improved drug activity against rifampicin-resistant Mycobacterium tuberculosis.Shared biosynthesis of the saliniketals and rifamycins in Salinispora arenicola is controlled by the sare1259-encoded cytochrome P450.An Amidinohydrolase Provides the Missing Link in the Biosynthesis of Amino Marginolactone AntibioticsThe blasticidin S biosynthesis gene cluster from Streptomyces griseochromogenes: sequence analysis, organization, and initial characterization.Mutational analysis and reconstituted expression of the biosynthetic genes involved in the formation of 3-amino-5-hydroxybenzoic acid, the starter unit of rifamycin biosynthesis in amycolatopsis Mediterranei S699.Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis.A single PLP-dependent enzyme PctV catalyzes the transformation of 3-dehydroshikimate into 3-aminobenzoate in the biosynthesis of pactamycin.Asm8, a specific LAL-type activator of 3-amino-5-hydroxybenzoate biosynthesis in ansamitocin production.A new method for rapid identification of ansamycin compounds by inactivating KLM gene clusters in potential ansamycin-producing actinomyces.Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892.A homologue of the Mycobacterium tuberculosis PapA5 protein, rif-orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.Cloning and functional analysis of the naphthomycin biosynthetic gene cluster in Streptomyces sp. CS.PCR screening reveals unexpected antibiotic biosynthetic potential in Amycolatopsis sp. strain UM16.Effects of the Methylmalonyl-CoA Metabolic Pathway on Ansamitocin Production in Actinosynnema pretiosum.Biosynthesis of hygrocins, antitumor naphthoquinone ansamycins produced by Streptomyces sp. LZ35.Enhanced rifamycin SV production by submerged fermentation using Amycolatopsis mediterranei.
P2860
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P2860
3-Amino-5-hydroxybenzoic acid synthase, the terminal enzyme in the formation of the precursor of mC7N units in rifamycin and related antibiotics.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
3-Amino-5-hydroxybenzoic acid ...... mycin and related antibiotics.
@en
3-Amino-5-hydroxybenzoic acid ...... mycin and related antibiotics.
@nl
type
label
3-Amino-5-hydroxybenzoic acid ...... mycin and related antibiotics.
@en
3-Amino-5-hydroxybenzoic acid ...... mycin and related antibiotics.
@nl
prefLabel
3-Amino-5-hydroxybenzoic acid ...... mycin and related antibiotics.
@en
3-Amino-5-hydroxybenzoic acid ...... mycin and related antibiotics.
@nl
P2093
P2860
P356
P1476
3-Amino-5-hydroxybenzoic acid ...... amycin and related antibiotics
@en
P2093
P2860
P304
P356
10.1074/JBC.273.11.6030
P407
P577
1998-03-01T00:00:00Z