A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.
about
The search for novel analgesics: targets and mechanismsAngiotensin Receptors: Structure, Function, Signaling and Clinical ApplicationsEpigenetic modification of DRG neuronal gene expression subsequent to nerve injury: etiological contribution to complex regional pain syndromes (Part II)Lost but making progress--Where will new analgesic drugs come from?Mechanisms underlying clinical efficacy of Angiotensin II type 2 receptor (AT2R) antagonist EMA401 in neuropathic pain: clinical tissue and in vitro studiesInternational Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].Structural basis for selectivity and diversity in angiotensin II receptorsAngiotensin-(1-7)/Mas receptor as an antinociceptive agent in cancer-induced bone pain.Emerging drugs for neuropathic pain.New investigational drugs for the treatment of neuropathic pain.Targeting angiotensin II type 2 receptor pathways to treat neuropathic pain and inflammatory pain.The therapeutic potential of renin angiotensin aldosterone system (RAAS) in chronic pain: from preclinical studies to clinical trials.Skeletal complications in cancer patients with bone metastases.Analgesic efficacy and mode of action of a selective small molecule angiotensin II type 2 receptor antagonist in a rat model of prostate cancer-induced bone pain.The role of slow and persistent TTX-resistant sodium currents in acute tumor necrosis factor-α-mediated increase in nociceptors excitability.Breaking barriers to novel analgesic drug development.Angiotensin II type 2-receptor: new clinically validated target in the treatment of neuropathic pain.Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.Basic/Translational Development of Forthcoming Opioid- and Nonopioid-Targeted Pain Therapeutics.Comment on "protective arms of the renin-angiotensin system in neurological disease".Attenuation of the Infiltration of Angiotensin II Expressing CD3+ T-Cells and the Modulation of Nerve Growth Factor in Lumbar Dorsal Root Ganglia - A Possible Mechanism Underpinning Analgesia Produced by EMA300, An Angiotensin II Type 2 (AT2) ReceptNorisoboldine attenuates inflammatory pain via the adenosine A1 receptor.
P2860
Q24288817-404640B0-DB20-4AA1-85DF-CC9CE94D7253Q26779600-8C3A004A-3D9A-45ED-BEFA-9E169474D69CQ33933720-4D855051-9245-4766-8534-0705ADDD0CF2Q35058471-8E15BA7C-7A17-4415-9B6B-04109DAAA251Q35786784-E5DF5552-9B31-41A3-A811-E9735C899D21Q36241932-8AE1D803-8D8A-48A5-9FF8-8D5D813EF9E7Q36335687-D91BB097-2780-45F8-8B3B-F205BB699E38Q37413252-3D148745-2BBC-41A6-AFCB-A0EE16E6CD58Q38209093-FBF05B0C-DCF2-43B7-B5C1-4C21D35CF075Q38217614-8160F418-88A6-4BD2-9DE2-9B9927D64AB9Q38260195-95354976-52B1-40B4-B17D-0592EA14F205Q38725329-A503929A-58E9-41E3-97D1-6381C700310FQ38917438-CFADC780-44A1-45EA-A130-7BF7A1137ABFQ39033886-A872FA54-2152-47D1-859E-7F40E0057671Q39199255-A2789731-B5C0-4582-9541-968E62128DA3Q39360773-AD898C1E-E0F2-4ACD-B901-0536F886681BQ41451854-D171962E-7A8F-42C7-96A1-04D82F126E78Q42775852-13650DF4-C81A-4754-97EE-624ABF0ACFB3Q43075742-6774495B-46E7-48F2-A964-EA1973C8C7A5Q45026464-18E31315-441F-4945-B197-0D430B0C3596Q47159630-7B023130-618F-46D3-B67A-C267869A5DC2Q54386310-35A069E0-734B-4B79-9ABA-0C0B46ECBD12
P2860
A small molecule angiotensin II type 2 receptor (AT₂R) antagonist produces analgesia in a rat model of neuropathic pain by inhibition of p38 mitogen-activated protein kinase (MAPK) and p44/p42 MAPK activation in the dorsal root ganglia.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh-hant
name
A small molecule angiotensin I ...... on in the dorsal root ganglia.
@en
A small molecule angiotensin II type 2 receptor
@nl
type
label
A small molecule angiotensin I ...... on in the dorsal root ganglia.
@en
A small molecule angiotensin II type 2 receptor
@nl
prefLabel
A small molecule angiotensin I ...... on in the dorsal root ganglia.
@en
A small molecule angiotensin II type 2 receptor
@nl
P2860
P50
P356
P1433
P1476
A small molecule angiotensin I ...... ion in the dorsal root ganglia
@en
P2093
Bruce D Wyse
Thomas Walther
P2860
P304
P356
10.1111/PME.12157
P577
2013-06-06T00:00:00Z