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Enhancing stereochemical diversity by means of microwave irradiation in the absence of solvent: synthesis of highly substituted nitroproline esters via 1,3-dipolar reactions.Development and validation of a LC-MS assay for the quantification of ikh12 a novel anti-tumor candidate in rat plasma and tissues and its application in a pharmacokinetic study.Aromaticity in transition structures.Chiral gold(I) vs chiral silver complexes as catalysts for the enantioselective synthesis of the second generation GSK-hepatitis C virus inhibitor.Design, synthesis, and functional evaluation of leukocyte function associated antigen-1 antagonists in early and late stages of cancer development.Identification of (1H)-pyrroles as histone deacetylase inhibitors with antitumoral activity.On the affinity regulation of the metal-ion-dependent adhesion sites in integrins.Stereodivergent synthesis of chiral fullerenes by [3 + 2] cycloadditions to C₆₀.Synthetic scope and DFT analysis of the chiral binap-gold(I) complex-catalyzed 1,3-dipolar cycloaddition of azlactones with alkenes.Formation of γ-oxoacids and 1H-pyrrol-2(5H)-ones from α,β-unsaturated ketones and ethyl nitroacetate.Concerted and stepwise mechanisms in metal-free and metal-assisted [4+3] cycloadditions involving allyl cations.Tandem [8 + 2] cycloaddition--[2 + 6 + 2] dehydrogenation reactions involving imidazo[1,2-a]pyridines and imidazo[1,2-a]pyrimidines.Quantitative evaluation of the catalytic activity of dendrimers with only one active center at the core: application to the nitroaldol (Henry) reaction.Aggregation and cooperative effects in the aldol reactions of lithium enolates.Pharmacokinetics and tissue distribution of Kendine 91, a novel histone deacetylase inhibitor, in mice.Mono- and Di-Alkylation Processes of DNA Bases by Nitrogen Mustard Mechlorethamine.Deeper insight into the mechanism of the reaction of photogenerated metallaketenes and imines.The mechanism of the ketene-imine (staudinger) reaction in its centennial: still an unsolved problem?Development and validation of a liquid chromatography-tandem mass spectrometry for the determination of Kendine 91, a novel histone deacetylase inhibitor, in mice plasma and tissues: application to a pharmacokinetic study.Regiochemistry of the microwave-assisted reaction between aromatic amines and alpha-bromoketones to yield substituted 1H-indoles.Comparative normal mode analysis of LFA-1 integrin I-domains.Catalysis of a 1,3-dipolar reaction by distorted DNA incorporating a heterobimetallic platinum(ii) and copper(ii) complex.Relevance of the DFT method to study expanded porphyrins with different topologies.Two-State Reactivity of Histone Demethylases Containing Jumonji-C Active Sites: Different Mechanisms for Different Methylation Degrees.Enantioselective Ring-Opening Polymerization of rac-Lactide Dictated by Densely Substituted Amino Acids.Density Functional Theory Study on the Demethylation Reaction between Methylamine, Dimethylamine, Trimethylamine, and Tamoxifen Catalyzed by a Fe(IV)-Oxo Porphyrin Complex.A Three-Component Enantioselective Cyclization Reaction Catalyzed by an Unnatural Amino Acid Derivative.Metal ion dependent adhesion sites in integrins: a combined DFT and QMC study on Mn2+.Synthesis of exo-Imidazolidin-2-one Dienes, Their Isomerization, and Selectivity in Diels-Alder Cycloadditions.Microwave-Assisted Organocatalyzed Rearrangement of Propargyl Vinyl Ethers to Salicylaldehyde Derivatives: An Experimental and Theoretical Study.Computational calculations in microwave-assisted organic synthesis (MAOS). Application to cycloaddition reactions.Cyclic carbodiphosphorane-diphosphinocarbene thermal interconversion.On the Aromatic Character of Electrocyclic and Pseudopericyclic Reactions: Thermal Cyclization of (2Z)-Hexa-2,4-5-trienals and Their Schiff Bases This work was supported by the Spanish Ministerio de Investigación (Grant no.: SAF98-0143), by the XuntSynthesis and Structure of a Base-Stabilized C-Phosphino-Si-Amino SilyneOrganocatalysts Derived from Unnatural α-Amino Acids: Scope and ApplicationsA Cationic Rh(III) Complex That Efficiently Catalyzes Hydrogen Isotope Exchange in HydrosilanesThe reaction of NH-indazoles with 1-fluoro-2,4-dinitrobenzene: the unusual formation of benzotriazole-N-oxidesCyclopropanation reactions catalysed by dendrimers possessing one metalloporphyrin active site at the core: linear and sigmoidal kinetic behaviour for different dendrimer generationsRemote Substituent Effects on the Stereoselectivity and Organocatalytic Activity of Densely Substituted Unnatural Proline Esters in Aldol ReactionsComputational insights on the possibility of tri-coordinated cisplatinated adducts with protein models
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Fernando P Cossío
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Fernando P Cossío
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