Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer. - Wikidata - wikimedia - TriplyDB

Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.

Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.

http://www.wikidata.org/entity/Q48071843

about

Mechanisms of Hippo pathway regulation A critical role for NF2 and the Hippo pathway in branching morphogenesis Current understanding concerning intestinal stem cells Drug Discovery via Human-Derived Stem Cell Organoids EGF receptor ligands: recent advances Long-Term Culture of Intestinal Cell Progenitors: An Overview of Their Development, Application, and Associated Technologies Targeting the Hippo Signaling Pathway for Tissue Regeneration and Cancer Therapy The Hippo Pathway Targets Rae1 to Regulate Mitosis and Organ Size and to Feed Back to Regulate Upstream Components Merlin, Hippo, and Warts Intestinal Epithelial Cell-Intrinsic Deletion of Setd7 Identifies Role for Developmental Pathways in Immunity to Helminth Infection Drosophila as a model for homeostatic, antibacterial, and antiviral mechanisms in the gut The Hippo pathway in tissue homeostasis and regeneration.TIAM1 Antagonizes TAZ/YAP Both in the Destruction Complex in the Cytoplasm and in the Nucleus to Inhibit Invasion of Intestinal Epithelial Cells The Hippo pathway effector YAP is an essential regulator of ductal progenitor patterning in the mouse submandibular gland.YAP Induces Human Naive Pluripotency Lawsonia intracellularis exploits β-catenin/Wnt and Notch signalling pathways during infection of intestinal crypt to alter cell homeostasis and promote cell proliferation.Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay Paneth Cell in Adenomas of the Distal Colorectum Is Inversely Associated with Synchronous Advanced Adenoma and Carcinoma.RAB and RHO GTPases regulate intestinal crypt cell homeostasis and enterocyte function.The Hippo effector TAZ (WWTR1) transforms myoblasts and TAZ abundance is associated with reduced survival in embryonal rhabdomyosarcoma.EpEX/EpCAM and Oct4 or Klf4 alone are sufficient to generate induced pluripotent stem cells through STAT3 and HIF2α.The Hippo signaling pathway provides novel anti-cancer drug targets.Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice.Investigating cell therapy for inflammatory bowel disease.The Hippo pathway in intestinal regeneration and disease.YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage.Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells.YAP/TAZ at the Roots of Cancer.MicroRNAs and Inflammation in Colorectal Cancer.Role of YAP/TAZ transcriptional regulators in resistance to anti-cancer therapies.Crosstalk between Hippo signalling and miRNAs in tumour progression.The EMT spectrum and therapeutic opportunities.Signaling and epigenetic mechanisms of intestinal stem cells and progenitors: insight into crypt homeostasis, plasticity, and niches.Wnt target genes and where to find them.R-spondin 2 promotes proliferation and migration via the Wnt/β-catenin pathway in human hepatocellular carcinoma.SNORA21 - An Oncogenic Small Nucleolar RNA, with a Prognostic Biomarker Potential in Human Colorectal Cancer.Role of Src family kinases in regulation of intestinal epithelial homeostasis.Knockdown of a DIS3L2 promoter upstream long noncoding RNA (AC105461.1) enhances colorectal cancer stem cell properties in vitro by down-regulating DIS3L2.Intestinal Stem Cell Niche Insights Gathered from Both In Vivo and Novel In Vitro Models.A Novel YAP1 Inhibitor targets CSCs-enriched Radiation Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma.Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.

P2860

Q26771285-DEDF4C2A-F96A-410F-AE29-80A2C0AA3E73 Q27334571-2F0E2454-6724-4011-B429-6A8268959D1D Q27694486-F11FD2DF-6968-4981-B5B4-1F2A82F4D826 Q28066424-BA2B1950-D6B5-4C4F-8814-57EFFC6D9298 Q28066531-5B3697E2-D003-43E0-A562-110D3E01EB67 Q28076085-09C2C468-B109-439E-B4F1-E6469655F8B3 Q28078129-4F08CDAC-4AB9-47EC-9992-7526BD910A63 Q28553403-0E3FD124-89F6-4154-8ABB-D3ABD5A69B3B Q28553906-4E608058-F18A-4FF5-8A1F-E9A6D3374D74 Q30250986-DE21DD80-19B2-4DE8-9725-A063FE8A5371 Q33628097-8136FB26-AF32-476A-B5FA-8E1D57775939 Q33658560-D2998353-906F-433F-89C3-4E5ECD521BA8 Q33784111-1EF0458A-85EB-482E-A5BF-08066D5B5255 Q34046392-2A6D736D-30EA-4F44-884E-88A5C744BDF5 Q36316600-0C27F3A4-96C2-4AD5-93F7-D56D36F1DC75 Q36831507-32F94C6F-AEFE-41FB-8520-97DDA642FE4B Q36910590-99CED155-1CDF-47B0-9957-C7DD67B4E18E Q36997840-FD4FCB85-157A-4B06-B6D0-C6819BFEB5B7 Q37199465-3AC1454B-68C7-4FC3-B29E-BE39D1B456B6 Q37623510-F5C5DF20-6B27-4C18-AA79-5BC8FFCB199E Q37716667-5AFFCC26-958F-41DF-BA55-2B8A1CF8180A Q38730228-E97399E4-F053-49F9-B88D-E0D59A0804E2 Q38817393-FB8B09FA-9501-4E7F-8FAB-3D021DF6FE3B Q38826172-7D60341C-F947-45EB-BFD4-0CCB5E1999B6 Q38833041-C1D91CAA-D4F2-4CF9-8A40-73AFF0031F08 Q38849795-D8E31D5F-0CA5-49CC-B695-E56DC9467693 Q38864941-0826D0DF-C98E-4FC2-BC10-FC980F62A139 Q38940592-FE4260D5-DF31-43D1-AF44-BB9C8609DF91 Q39003420-57ACE458-C528-4450-8547-54399CB0AA98 Q39038455-7F542ADD-6009-44F5-80B8-BA0734C021EA Q39329818-8A774AD9-BD93-431C-A302-3A5840CDF730 Q39394470-048FD6F5-3F51-4915-AB64-F53414699F54 Q39397771-25C7359D-A1E8-4BAE-86C1-02AB4455BA49 Q41142284-F9028335-1048-4BD8-9D26-53021EC5E88D Q41348590-AE691A47-FC5E-4FFF-88C2-E752881CC7C6 Q41619825-6FD5568D-5AFC-4EE9-9481-6DB5263854A7 Q41948743-7E18F312-75BA-4D93-A7B0-77D57A49F8CC Q42730658-05BA5FC2-3D35-4D0B-92E1-E9EA74D4379B Q46115640-FCE4A4AF-095E-47C6-8965-FB518D77D675 Q46468725-5280B9CC-B1FE-45CB-9112-DC353BA7C31D

P2860

Yap-dependent reprogramming of Lgr5(+) stem cells drives intestinal regeneration and cancer.

http://www.wikidata.org/entity/Q48071843

description

2015 nî lūn-bûn

@nan

2015年の論文

@ja

2015年学术文章

@wuu

2015年学术文章

@zh-cn

2015年学术文章

@zh-hans

2015年学术文章

@zh-my

2015年学术文章

@zh-sg

2015年學術文章

@yue

2015年學術文章

@zh

2015年學術文章

@zh-hant

name

Yap-dependent reprogramming of Lgr5

@nl

Yap-dependent reprogramming of ...... tinal regeneration and cancer.

@en

type

label

Yap-dependent reprogramming of Lgr5

@nl

Yap-dependent reprogramming of ...... tinal regeneration and cancer.

@en

prefLabel

Yap-dependent reprogramming of Lgr5

@nl

Yap-dependent reprogramming of ...... tinal regeneration and cancer.

@en

P1433

Q48071843-62DD4B79-772B-42FC-9B64-E2DE190CBC7F

P1476

Q48071843-0C78251A-3202-4416-9B85-608BE5E64794

P2093

Q48071843-441E7789-4A16-4EEF-A3F7-4A4BA42A0576

Q48071843-44C909C3-1782-4203-9119-A761B2C32AAD

Q48071843-543547DA-8710-4039-99E8-AAC3F9E5F1EC

Q48071843-57C9E2E6-DD64-42A8-B26A-FC62765D540D

Q48071843-CC95FEEA-31A9-4D65-B0B6-4AFD98D7287F

P2860

Q48071843-02C5D71B-E502-443E-B980-F6FD54AC2B9E

Q48071843-088469B9-2D93-43B8-B5A4-3419C35C15A9

Q48071843-0AFE634B-30E3-4676-8039-A6F8D604196A

Q48071843-14939F1F-7B90-420B-8C67-0D6071D56901

Q48071843-17D3D3C0-FDD2-45A0-8E40-938761AFFE7B

Q48071843-1BA40A8D-6022-4705-B681-03356E907FEC

Q48071843-21B210EF-C6E6-4AE6-9381-92B90E775FF0

Q48071843-28681FEB-E903-4537-B946-A224DA2014CA

Q48071843-2E81443A-D274-4178-8A6E-FBDE3E8703EC

Q48071843-30638910-F6FC-46A2-A7C9-3D7C9495B543

P2888

Q48071843-7C17DB7A-A8D4-4531-84EB-D7445BD0DB74

P304

Q48071843-ADF77053-81FD-423B-A8A6-40C72EBFB88E

P31

Q48071843-17AB105A-ABE5-4F3F-9810-A9966E67D0BE

P356

Q48071843-F67A47F2-7F0C-4300-92EA-D8A844007C5D

P407

Q48071843-4CDE553E-5B1A-4FCC-B025-D3DB2D85F626

P433

Q48071843-1FAC6BD0-B154-486F-AA1E-D9A2F7B5695E

P478

Q48071843-C93C0C28-297C-463F-A921-F5EED5E06A3F

P577

Q48071843-3E08AD62-AB7F-4EB5-A82C-FB5D8F9CBEFF

P6179

Q48071843-56F0FD80-9287-4082-ACB3-72C8EC719CAE

P698

Q48071843-BEFC8A2B-5E14-4264-943E-153DCD5E3D3C

P356

P1433

P1476

Yap-dependent reprogramming of ...... tinal regeneration and cancer.

@en

P2093

Alex Gregorieff

http://www.w3.org/2001/XMLSchema#string

Jeffrey L Wrana

http://www.w3.org/2001/XMLSchema#string

Mohammad R Inanlou

http://www.w3.org/2001/XMLSchema#string

Yu Liu

http://www.w3.org/2001/XMLSchema#string

Yuliya Khomchuk

http://www.w3.org/2001/XMLSchema#string

P2860

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

A molecular mechanism that links Hippo signalling to the inhibition of Wnt/β-catenin signalling

The Hippo pathway regulates Wnt/beta-catenin signaling

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

Yap- and Cdc42-dependent nephrogenesis and morphogenesis during mouse kidney development

Identification of stem cells in small intestine and colon by marker gene Lgr5

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Wnt signalling induces maturation of Paneth cells in intestinal crypts

YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway.

Amphiregulin promotes intestinal epithelial regeneration: roles of intestinal subepithelial myofibroblasts.

P2888

P304

715-718

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/NATURE15382

http://www.w3.org/2001/XMLSchema#string

P407

P433

7575

http://www.w3.org/2001/XMLSchema#string

P478

526

http://www.w3.org/2001/XMLSchema#string

P577

2015-10-21T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P6179

1017213436

http://www.w3.org/2001/XMLSchema#string

P698

26503053

http://www.w3.org/2001/XMLSchema#string