Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.
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Mutant ubiquitin (UBB+1) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3)The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord InjuryMisframed ubiquitin and impaired protein quality control: an early event in Alzheimer's diseaseStructural Basis of E2-25K/UBB+1 Interaction Leading to Proteasome Inhibition and NeurotoxicityArgyrophilic grain diseaseThe ubiquitin proteasome system in glia and its role in neurodegenerative diseasesE2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicityMutant ubiquitin UBB+1 induces mitochondrial fusion by destabilizing mitochondrial fission-specific proteins and confers resistance to oxidative stress-induced cell death in astrocytic cellsDisease-associated mutant ubiquitin causes proteasomal impairment and enhances the toxicity of protein aggregates.Selective Transgenic Expression of Mutant Ubiquitin in Purkinje Cell Stripes in the Cerebellum.Ubiquitin regulates GGA3-mediated degradation of BACE1Β-site APP-cleaving enzyme 1 trafficking and Alzheimer's disease pathogenesis.Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.HUWE1 and TRIP12 collaborate in degradation of ubiquitin-fusion proteins and misframed ubiquitin.Mutation in E1, the ubiquitin activating enzyme, reduces Drosophila lifespan and results in motor impairment.Ubiquitin over-expression phenotypes and ubiquitin gene molecular misreading during aging in Drosophila melanogasterLocalization of mutant ubiquitin in the brain of a transgenic mouse line with proteasomal inhibition and its validation at specific sites in Alzheimer's diseasePiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomesAccumulation of Basic Amino Acids at Mitochondria Dictates the Cytotoxicity of Aberrant UbiquitinExtended ubiquitin species are protein-based DUB inhibitors.Indirect inhibition of 26S proteasome activity in a cellular model of Huntington's disease.Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.Water and ion channels: crucial in the initiation and progression of apoptosis in central nervous system?Ubiquitin degradation with its substrate, or as a monomer in a ubiquitination-independent mode, provides clues to proteasome regulation.Stressing the ubiquitin-proteasome system.Review: unchained maladie - a reassessment of the role of Ubb(+1) -capped polyubiquitin chains in Alzheimer's disease.Molecular basis of etiological implications in Alzheimer's disease: focus on neuroinflammation.Protein recycling pathways in neurodegenerative diseases.Ubiquitin-dependent proteolysis in yeast cells expressing neurotoxic proteins.The fine-tuning of proteolytic pathways in Alzheimer's disease.Role of frameshift ubiquitin B protein in Alzheimer's disease.Mutant ubiquitin attenuates interleukin-1β- and tumor necrosis factor-α-induced pro-inflammatory signaling in human astrocytic cells.Intermediate filament transcription in astrocytes is repressed by proteasome inhibition.Mutant ubiquitin-mediated beta-secretase stability via activation of caspase-3 is related to beta-amyloid accumulation in ischemic striatum in rats.Characterizing polyubiquitinated forms of the neurodegenerative ubiquitin mutant UBB+1.Tauopathies: Mechanisms and Therapeutic Strategies.Identification and characterization of RING-finger ubiquitin ligase UBR7 in mammalian spermatozoa.Dysfunction of Protein Quality Control in Parkinsonism-Dementia Complex of Guam.Different Expression Levels of Human Mutant Ubiquitin B+1 (UBB+1) Can Modify Chronological Lifespan or Stress Resistance of Saccharomyces cerevisiae.
P2860
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P2860
Dose-dependent inhibition of proteasome activity by a mutant ubiquitin associated with neurodegenerative disease.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh-hant
name
Dose-dependent inhibition of p ...... ith neurodegenerative disease.
@en
Dose-dependent inhibition of p ...... ith neurodegenerative disease.
@nl
type
label
Dose-dependent inhibition of p ...... ith neurodegenerative disease.
@en
Dose-dependent inhibition of p ...... ith neurodegenerative disease.
@nl
prefLabel
Dose-dependent inhibition of p ...... ith neurodegenerative disease.
@en
Dose-dependent inhibition of p ...... ith neurodegenerative disease.
@nl
P2093
P50
P356
P1476
Dose-dependent inhibition of p ...... ith neurodegenerative disease.
@en
P2093
Femke M S de Vrij
Fred W van Leeuwen
Karianne G Schuurman
Paula van Tijn
P304
P356
10.1242/JCS.03438
P407
P577
2007-04-03T00:00:00Z