Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).
about
Structure, function, and evolution of bacterial ATP-binding cassette systemsMechanisms of drug resistance in colon cancer and its therapeutic strategiesBlood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in strokeTransmembrane passage of hydrophobic compounds through a protein channel wallDiscovery of the inhibitory effect of a phosphatidylinositol derivative on P-glycoprotein by virtual screening followed by in vitro cellular studiesChallenges of using in vitro data for modeling P-glycoprotein efflux in the blood-brain barrier.Kinetic validation of the models for P-glycoprotein ATP hydrolysis and vanadate-induced trapping. Proposal for additional steps.Amyloid-beta transporter expression at the blood-CSF barrier is age-dependent.Targeting blood-brain barrier changes during inflammatory pain: an opportunity for optimizing CNS drug delivery.Application of fluorescent dye substrates for functional characterization of ABC multidrug transporters at a single cell level.The ATPase activity of the P-glycoprotein drug pump is highly activated when the N-terminal and central regions of the nucleotide-binding domains are linked closely togetherPhorbol 12-myristate 13-acetate inhibits P-glycoprotein-mediated efflux of digoxin in MDCKII-MDR1 and Caco-2 cell monolayer models.The multidrug transporter ABCG2 (BCRP) is inhibited by plant-derived cannabinoids.A single active catalytic site is sufficient to promote transport in P-glycoproteinMass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pumpMRP isoforms and BCRP mediate sulfate conjugate efflux out of BeWo cells.Complex Interplay between the P-Glycoprotein Multidrug Efflux Pump and the Membrane: Its Role in Modulating Protein Function.Identification of the distance between the homologous halves of P-glycoprotein that triggers the high/low ATPase activity switch.Future Perspectives for Brain Pharmacotherapies: Implications of Drug Transport Processes at the Blood-brain Barrier.A salt bridge in intracellular loop 2 is essential for folding of human p-glycoprotein.Multidrug resistance protein gene expression in Trichoplusia ni caterpillars.Drug rescue distinguishes between different structural models of human P-glycoproteinThe impact of P-gp functionality on non-steady state relationships between CSF and brain extracellular fluid.The effect of P-glycoprotein on methadone hydrochloride flux in equine intestinal mucosa.Nucleotide-induced structural changes in P-glycoprotein observed by electron microscopy.Functional characterization of Escherichia coli MsbA: interaction with nucleotides and substrates.
P2860
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P2860
Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1).
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh-hant
name
Shedding light on drug transpo ...... multidrug transporter (ABCB1).
@en
Shedding light on drug transpo ...... oprotein multidrug transporter
@nl
type
label
Shedding light on drug transpo ...... multidrug transporter (ABCB1).
@en
Shedding light on drug transpo ...... oprotein multidrug transporter
@nl
prefLabel
Shedding light on drug transpo ...... multidrug transporter (ABCB1).
@en
Shedding light on drug transpo ...... oprotein multidrug transporter
@nl
P2860
P356
P1476
Shedding light on drug transpo ...... multidrug transporter (ABCB1).
@en
P2860
P304
P356
10.1139/O06-199
P577
2006-12-01T00:00:00Z