Ischemic preconditioning reveals that GLT1/EAAT2 glutamate transporter is a novel PPARgamma target gene involved in neuroprotection. - Wikidata - wikimedia - TriplyDB

Ischemic preconditioning reveals that GLT1/EAAT2 glutamate transporter is a novel PPARgamma target gene involved in neuroprotection.

Ischemic preconditioning reveals that GLT1/EAAT2 glutamate transporter is a novel PPARgamma target gene involved in neuroprotection.

http://www.wikidata.org/entity/Q48314707

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Opposite Interplay between PPAR Gamma and Canonical Wnt/Beta-Catenin Pathway in Amyotrophic Lateral Sclerosis Ischemic conditioning-induced endogenous brain protection: Applications pre-, per- or post-stroke Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation Electroacupuncture preconditioning-induced neuroprotection may be mediated by glutamate transporter type 2.Regulatory role of cannabinoid receptor 1 in stress-induced excitotoxicity and neuroinflammation.The Concise Guide to PHARMACOLOGY 2013/14: transporters.Effects of long-term pioglitazone treatment on peripheral and central markers of aging.Activation of NR2A receptors induces ischemic tolerance through CREB signaling.Low-dose alcohol consumption protects against transient focal cerebral ischemia in mice: possible role of PPARγ.Expression of astrocytic genes coding for proteins implicated in neural excitation and brain edema is altered after acute liver failure.Involvement of Glutamate transporter-1 in neuroprotection against global brain ischemia-reperfusion injury induced by postconditioning in rats.Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics.The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria.12/15-Lipoxygenase metabolites of arachidonic acid activate PPARγ: a possible neuroprotective effect in ischemic brain Pre-conditioning induces the precocious differentiation of neonatal astrocytes to enhance their neuroprotective properties.PPAR gamma activation is neuroprotective in a Drosophila model of ALS based on TDP-43.Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity.The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention.Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia.The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells.Glutamate transporters in brain ischemia: to modulate or not?N-Acetylcysteine and Ceftriaxone as Preconditioning Strategies in Focal Brain Ischemia: Influence on Glutamate Transporters Expression.Estrogen attenuates manganese-induced glutamate transporter impairment in rat primary astrocytes Potential Therapeutic Targets for PPARgamma after Spinal Cord Injury.Regulation of Glial Cell Functions by PPAR-gamma Natural and Synthetic Agonists.Preconditioning and tolerance against cerebral ischaemia: from experimental strategies to clinical use.Reduced early hypoxic/ischemic brain damage is associated with increased GLT-1 levels in mice expressing mutant (P301L) human tau.Neuronal PPARgamma deficiency increases susceptibility to brain damage after cerebral ischemia.PPARs as new therapeutic targets for the treatment of cerebral ischemia/reperfusion injury.PPAR agonists as therapeutics for CNS trauma and neurological diseases Pioglitazone, a PPARγ agonist rescues depression associated with obesity using chronic unpredictable mild stress model in experimental mice.The potential role of glutamate in the current diabetes epidemic.Ischemic tolerance in the brain: endogenous adaptive machinery against ischemic stress.Oligodendrocyte pathophysiology and treatment strategies in cerebral ischemia.Pleiotropic role of PPARγ in intracerebral hemorrhage: an intricate system involving Nrf2, RXR, and NF-κB.Neurotransmitters and Neuropeptides: New Players in the Control of Islet of Langerhans' Cell Mass and Function.Metabolic and Inflammatory Adaptation of Reactive Astrocytes: Role of PPARs.Excitatory amino acid transporter 2 and excitatory amino acid transporter 1 negatively regulate calcium-dependent proliferation of hippocampal neural progenitor cells and are persistently upregulated after injury Peroxisome proliferator-activated receptor-gamma: potential molecular therapeutic target for HIV-1-associated brain inflammation.Distinct modulation of voltage-gated and ligand-gated Ca2+ currents by PPAR-gamma agonists in cultured hippocampal neurons.

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P2860

Ischemic preconditioning reveals that GLT1/EAAT2 glutamate transporter is a novel PPARgamma target gene involved in neuroprotection.

http://www.wikidata.org/entity/Q48314707

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2007 nî lūn-bûn

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Ischemic preconditioning revea ...... e involved in neuroprotection.

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Ischemic preconditioning revea ...... e involved in neuroprotection.

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Ischemic preconditioning revea ...... e involved in neuroprotection.

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Ischemic preconditioning revea ...... e involved in neuroprotection.

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Journal of Cerebral Blood Flow & Metabolism

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Alejandro Romera

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Cristina Romera

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Florentino Nombela

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Jesús R Morales

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Joaquín Serena

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José Vivancos

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Judith Mallolas

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Pedro Lorenzo

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P2860

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma

Gene expression profiling of potential peroxisome proliferator-activated receptor (PPAR) target genes in human hepatoblastoma cell lines inducibly expressing different PPAR isoforms

Glutamate uptake

Inhibition of glutamate release via recovery of ATP levels accounts for a neuroprotective effect of aspirin in rat cortical neurons exposed to oxygen-glucose deprivation

Cloning and expression of a rat brain L-glutamate transporter

Molecular cloning of human brain glutamate/aspartate transporter II

Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis

TACE/ADAM17-TNF-alpha pathway in rat cortical cultures after exposure to oxygen-glucose deprivation or glutamate

Peroxisome proliferator-activated receptor gamma activation decreases neuroinflammation in brain after stress in rats

Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1

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10.1038/SJ.JCBFM.9600438

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7

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27

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Ignacio Lizasoain

Marta P Pereira

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