Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus. - Wikidata - wikimedia - TriplyDB

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.

Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.

http://www.wikidata.org/entity/Q48363576

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Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2).Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.Expression and processing analyses of wild type and p.R47H TREM2 variant in Alzheimer's disease brains.The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.Rare TREM2 variants associated with Alzheimer's disease display reduced cell surface expression Regulation of amyloid precursor protein processing by its KFERQ motif.The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E.TREM2 in Neurodegenerative Diseases.The Triggering Receptor Expressed on Myeloid Cells 2: A Molecular Link of Neuroinflammation and Neurodegenerative Diseases TREM2-Ligand Interactions in Health and Disease.The Alzheimer's disease risk factors apolipoprotein E and TREM2 are linked in a receptor signaling pathway Proteomics as an innovative tool to investigate frontotemporal disorders.Identification of a rare coding variant in TREM2 in a Chinese individual with Alzheimer's disease Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseases.TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects Neurodegeneration-associated mutant TREM2 proteins abortively cycle between the ER and ER-Golgi intermediate compartment.Intracellular trafficking of TREM2 is regulated by presenilin 1.Microglia and Aging: The Role of the TREM2-DAP12 and CX3CL1-CX3CR1 Axes.Vps35-dependent recycling of Trem2 regulates microglial function.Linking Glycation and Glycosylation With Inflammation and Mitochondrial Dysfunction in Parkinson’s Disease.Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.The Trem2 R47H variant confers loss-of-function-like phenotypes in Alzheimer's disease.The Alzheimer's Disease-Associated R47H Variant of TREM2 Has an Altered Glycosylation Pattern and Protein Stability Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain

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Disease-Associated Mutations of TREM2 Alter the Processing of N-Linked Oligosaccharides in the Golgi Apparatus.

http://www.wikidata.org/entity/Q48363576

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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2015年學術文章

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Disease-Associated Mutations o ...... arides in the Golgi Apparatus.

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Dong-Hou Kim

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In Jung Ji

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Ji-Seon Park

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Min-Ji Kang

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Sang-Wook Kang

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Seung-Yong Yoon

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P2860

Endocytosis, actin cytoskeleton, and signaling

Endoplasmic reticulum-associated degradation (ERAD) and autophagy cooperate to degrade polymerogenic mutant serpins

An Italian family affected by Nasu-Hakola disease with a novel genetic mutation in the TREM2 gene

Impaired differentiation of osteoclasts in TREM-2-deficient individuals

Novel compound heterozygous mutation in TREM2 found in a Turkish frontotemporal dementia-like family

Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice

Using exome sequencing to reveal mutations in TREM2 presenting as a frontotemporal dementia-like syndrome without bone involvement

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer's disease.

Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.

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10.1111/TRA.12264

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5

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16

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oligosaccharide

Golgi apparatus