Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel.
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Sulfhydryl modification of V449C in the glutamate transporter EAAT1 abolishes substrate transport but not the substrate-gated anion conductanceDiversity of Cl(-) channelsNiflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunitsThe sodium-coupled neutral amino acid transporter SNAT2 mediates an anion leak conductance that is differentially inhibited by transported substratesExcitatory amino acid transporters: roles in glutamatergic neurotransmissionThe density of EAAC1 (EAAT3) glutamate transporters expressed by neurons in the mammalian CNSWater transport by the human Na+-coupled glutamate cotransporter expressed in Xenopus oocytesFunctional properties of the retinal glutamate transporters GLT-1c and EAAT5Individual subunits of the glutamate transporter EAAC1 homotrimer function independently of each otherCurrent carried by the Slc26 family member prestin does not flow through the transporter pathway.Intrinsic kinetics determine the time course of neuronal synaptic transporter currents.Glutamate transporter-mediated glutamate secretion in the mammalian pineal gland.Synaptic and extrasynaptic factors governing glutamatergic retinal waves.The central cavity in trimeric glutamate transporters restricts ligand diffusion.Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression.Glutamate translocation of the neuronal glutamate transporter EAAC1 occurs within milliseconds.Early intermediates in the transport cycle of the neuronal excitatory amino acid carrier EAAC1Neutralization of the aspartic acid residue Asp-367, but not Asp-454, inhibits binding of Na+ to the glutamate-free form and cycling of the glutamate transporter EAAC1.Disulfide cross-linking of transport and trimerization domains of a neuronal glutamate transporter restricts the role of the substrate to the gating of the anion conductanceGlial and Neuronal Glutamate Transporters Differ in the Na+ Requirements for Activation of the Substrate-Independent Anion ConductanceSubstrate transport and anion permeation proceed through distinct pathways in glutamate transporters.Sodium-dependent extracellular accessibility of Lys-84 in the sodium/dicarboxylate cotransporterMechanism of cation binding to the glutamate transporter EAAC1 probed with mutation of the conserved amino acid residue Thr101.The discovery of slowness: low-capacity transport and slow anion channel gating by the glutamate transporter EAAT5.A conserved methionine residue controls the substrate selectivity of a neuronal glutamate transporter.The domain interface of the human glutamate transporter EAAT1 mediates chloride permeationIon/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters.Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2.Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1.EAAT2 (GLT-1; slc1a2) glutamate transporters reconstituted in liposomes argues against heteroexchange being substantially faster than net uptakeHetero-oligomerization of neuronal glutamate transportersNew views of glutamate transporter structure and function: advances and challenges.Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation.Transport rates of a glutamate transporter homologue are influenced by the lipid bilayer.GluN2B subunit deletion reveals key role in acute and chronic ethanol sensitivity of glutamate synapses in bed nucleus of the stria terminalis.GLT-1 Transport Stoichiometry Is Constant at Low and High Glutamate Concentrations when Chloride Is Substituted by Gluconate.A conserved aspartate residue located at the extracellular end of the binding pocket controls cation interactions in brain glutamate transportersThe mode of retinal presynaptic inhibition switches with light intensity.Pharmacological inhibitions of glutamate transporters EAAT1 and EAAT2 compromise glutamate transport in photoreceptor to ON-bipolar cell synapses.
P2860
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P2860
Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh-hant
name
Macroscopic and microscopic pr ...... transporter/chloride channel.
@en
Macroscopic and microscopic pr ...... transporter/chloride channel.
@nl
type
label
Macroscopic and microscopic pr ...... transporter/chloride channel.
@en
Macroscopic and microscopic pr ...... transporter/chloride channel.
@nl
prefLabel
Macroscopic and microscopic pr ...... transporter/chloride channel.
@en
Macroscopic and microscopic pr ...... transporter/chloride channel.
@nl
P1476
Macroscopic and microscopic properties of a cloned glutamate transporter/chloride channel
@en
P2093
J I Wadiche
M P Kavanaugh
P304
P356
10.1523/JNEUROSCI.18-19-07650.1998
P407
P577
1998-10-01T00:00:00Z