Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
about
MiR-221/222 target the DNA methyltransferase MGMT in glioma cellsTransfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agentsEarly Chk1 phosphorylation is driven by temozolomide-induced, DNA double strand break- and mismatch repair-independent DNA damageEnhanced anti-tumor effect of zoledronic acid combined with temozolomide against human malignant glioma cell expressing O6-methylguanine DNA methyltransferaseTemozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 ExpressionVorinostat Enhances Cytotoxicity of SN-38 and Temozolomide in Ewing Sarcoma Cells and Activates STAT3/AKT/MAPK PathwaysNRF2 and glutathione are key resistance mediators to temozolomide in glioma and melanoma cellsTemozolomide treatment for aggressive pituitary tumors: correlation of clinical outcome with O(6)-methylguanine methyltransferase (MGMT) promoter methylation and expressionA nanoparticle carrying the p53 gene targets tumors including cancer stem cells, sensitizes glioblastoma to chemotherapy and improves survival.JLK1486, a Bis 8-Hydroxyquinoline-Substituted Benzylamine, Displays Cytostatic Effects in Experimental Gliomas through MyT1 and STAT1 Activation and, to a Lesser Extent, PPARĪ³ ActivationA chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells.WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration.Dose-dense temozolomide regimen for the treatment of brain metastases from melanoma, breast cancer, or lung cancer not amenable to surgery or radiosurgery: a multicenter phase II study.Long-term temozolomide treatment induces marked amino metabolism modifications and an increase in TMZ sensitivity in Hs683 oligodendroglioma cellsQuercetin abrogates chemoresistance in melanoma cells by modulating deltaNp73.Immunological factors relating to the antitumor effect of temozolomide chemoimmunotherapy in a murine glioma model.IDH1 R132H mutation regulates glioma chemosensitivity through Nrf2 pathway.First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response.Ependymoma stem cells are highly sensitive to temozolomide in vitro and in orthotopic models.Cytotoxic autophagy in cancer therapy.Pathologies associated with the p53 response.Clinically relevant doses of chemotherapy agents reversibly block formation of glioblastoma neurospheres.Rad51 and BRCA2--New molecular targets for sensitizing glioma cells to alkylating anticancer drugs.A rapid survival assay to measure drug-induced cytotoxicity and cell cycle effects.Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression.Is there a common upstream link for autophagic and apoptotic cell death in human high-grade gliomas?Alkyltransferase-like protein (eATL) prevents mismatch repair-mediated toxicity induced by O6-alkylguanine adducts in Escherichia coli.Activation of AMP-activated protein kinase by temozolomide contributes to apoptosis in glioblastoma cells via p53 activation and mTORC1 inhibition.Initial testing (stage 1) of temozolomide by the pediatric preclinical testing programSurvival and death strategies in glioma cells: autophagy, senescence and apoptosis triggered by a single type of temozolomide-induced DNA damage.APO010, a synthetic hexameric CD95 ligand, induces human glioma cell death in vitro and in vivo.Temozolomide modifies caveolin-1 expression in experimental malignant gliomas in vitro and in vivo.Overcoming temozolomide resistance in glioblastoma via dual inhibition of NAD+ biosynthesis and base excision repairN-(2-hydroxyphenyl)acetamide (NA-2) and Temozolomide synergistically induce apoptosis in human glioblastoma cell line U87.A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme.CRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma.The human RECQ1 helicase is highly expressed in glioblastoma and plays an important role in tumor cell proliferation.Chemoresistance of glioblastoma cancer stem cells--much more complex than expected.Unlocking the promise of oncolytic virotherapy in glioma: combination with chemotherapy to enhance efficacyIdentification of a novel pro-apopotic function of NF-kappaB in the DNA damage response.
P2860
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P2860
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine.
description
2006 nĆ® lÅ«n-bĆ»n
@nan
2006幓ć®č«ę
@ja
2006幓å¦ęÆęē«
@wuu
2006幓å¦ęÆęē«
@zh
2006幓å¦ęÆęē«
@zh-cn
2006幓å¦ęÆęē«
@zh-hans
2006幓å¦ęÆęē«
@zh-my
2006幓å¦ęÆęē«
@zh-sg
2006幓åøč”ęē«
@yue
2006幓åøč”ęē«
@zh-hant
name
Apoptosis in malignant glioma ...... d DNA lesion O6-methylguanine.
@en
Apoptosis in malignant glioma ...... d DNA lesion O6-methylguanine.
@nl
type
label
Apoptosis in malignant glioma ...... d DNA lesion O6-methylguanine.
@en
Apoptosis in malignant glioma ...... d DNA lesion O6-methylguanine.
@nl
prefLabel
Apoptosis in malignant glioma ...... d DNA lesion O6-methylguanine.
@en
Apoptosis in malignant glioma ...... d DNA lesion O6-methylguanine.
@nl
P2093
P356
P1433
P1476
Apoptosis in malignant glioma ...... d DNA lesion O6-methylguanine.
@en
P2093
C F M Menck
L F Z Batista
S C Naumann
P2888
P304
P356
10.1038/SJ.ONC.1209785
P407
P577
2006-07-03T00:00:00Z
P5875
P6179
1009706483