Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.
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Transthyretin and the brain re-visited: is neuronal synthesis of transthyretin protective in Alzheimer's disease?Soluble amyloid precursor protein (APP) regulates transthyretin and Klotho gene expression without rescuing the essential function of APPThe associations between Parkinson's disease and cancer: the plot thickensDeletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic miceAtaxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factorLoss of alpha7 nicotinic receptors enhances beta-amyloid oligomer accumulation, exacerbating early-stage cognitive decline and septohippocampal pathology in a mouse model of Alzheimer's disease.APP transgenic mice for modelling behavioural and psychological symptoms of dementia (BPSD).Transcriptional signatures of brain aging and Alzheimer's disease: What are our rodent models telling us?Transthyretin variants with improved inhibition of β-amyloid aggregation.Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor.Amyloid oligomer conformation in a group of natively folded proteins.The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice.Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative DisordersTransthyretin-derived peptides as β-amyloid inhibitors.Neurotoxic mechanisms of DNA damage: focus on transcriptional inhibition.Characterization of the interaction of β-amyloid with transthyretin monomers and tetramers.Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus.Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse modelGenetic determinants at the interface of cancer and neurodegenerative disease.Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease.Effective screen for amyloid β aggregation inhibitor using amyloid β-conjugated gold nanoparticles.Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway.Temporal gene profiling of the 5XFAD transgenic mouse model highlights the importance of microglial activation in Alzheimer's disease.Evidence for defective retinoid transport and function in late onset Alzheimer's diseaseInsulin-like growth factor 2 reverses memory and synaptic deficits in APP transgenic miceNeuroinflammation and memory: the role of prostaglandinsRegulation of Neuronal Function by Ras-GRF Exchange Factors.Effects of n-3 FA supplementation on the release of proresolving lipid mediators by blood mononuclear cells: the OmegAD studyNeuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?Presenilins regulate the cellular level of the tumor suppressor PTEN.A Cyclic Peptide Mimic of the β-Amyloid Binding Domain on Transthyretin.Transthyretin Induces Insulin-like Growth Factor I Nuclear Translocation Regulating Its Levels in the HippocampusMechanisms of ceramide-mediated neurodegeneration.TANGO-Inspired Design of Anti-Amyloid Cyclic Peptides.Identification of beta-amyloid-binding sites on transthyretin.Transthyretin protects Alzheimer's mice from the behavioral and biochemical effects of Abeta toxicity.Insulin receptor signaling mediates APP processing and β-amyloid accumulation without altering survival in a transgenic mouse model of Alzheimer's diseaseTransthyretin: the servant of many masters.Transthyretin as both a sensor and a scavenger of β-amyloid oligomersDifferential modification of Cys10 alters transthyretin's effect on beta-amyloid aggregation and toxicity.
P2860
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P2860
Lack of neurodegeneration in transgenic mice overexpressing mutant amyloid precursor protein is associated with increased levels of transthyretin and the activation of cell survival pathways.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh-hant
name
Lack of neurodegeneration in t ...... ion of cell survival pathways.
@en
Lack of neurodegeneration in t ...... ion of cell survival pathways.
@nl
type
label
Lack of neurodegeneration in t ...... ion of cell survival pathways.
@en
Lack of neurodegeneration in t ...... ion of cell survival pathways.
@nl
prefLabel
Lack of neurodegeneration in t ...... ion of cell survival pathways.
@en
Lack of neurodegeneration in t ...... ion of cell survival pathways.
@nl
P1476
Lack of neurodegeneration in t ...... tion of cell survival pathways
@en
P2093
Jeffrey A Johnson
P304
P356
10.1523/JNEUROSCI.22-17-07380.2002
P407
P50
P577
2002-09-01T00:00:00Z