The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity.
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The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic PotentialRedox-Dependent Modulation of T-Type Ca(2+) Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance PNMP-7 inhibits chronic inflammatory and neuropathic pain via block of Cav3.2 T-type calcium channels and activation of CB2 receptors.Small organic molecule disruptors of Cav3.2 - USP5 interactions reverse inflammatory and neuropathic pain.Standardized Profiling of The Membrane-Enriched Proteome of Mouse Dorsal Root Ganglia (DRG) Provides Novel Insights Into Chronic Pain.Poly-arginine peptides reduce infarct volume in a permanent middle cerebral artery rat stroke modelWnt-induced deubiquitination FoxM1 ensures nucleus β-catenin transactivation.Inflammatory mediator bradykinin increases population of sensory neurons expressing functional T-type Ca(2+) channels.USP5 Is Dispensable for Monoubiquitin Maintenance in DrosophilaA cell-permeant peptide corresponding to the cUBP domain of USP5 reverses inflammatory and neuropathic pain.Modulation of nociceptive ion channels and receptors via protein-protein interactions: implications for pain relief.Targeting voltage-gated calcium channels in neurological and psychiatric diseases.Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain.Regulation of the T-type Ca(2+) channel Cav3.2 by hydrogen sulfide: emerging controversies concerning the role of H2 S in nociception.Analgesic effect of a broad-spectrum dihydropyridine inhibitor of voltage-gated calcium channels.Targeting Deubiquitinating Enzymes in Glioblastoma Multiforme: Expectations and Challenges.Recent advances in the development of T-type calcium channel blockers for pain intervention.Synthesis and characterization of a disubstituted piperazine derivative with T-type channel blocking action and analgesic properties.A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane.Genetic alteration of the metal/redox modulation of Cav3.2 T-type calcium channel reveals its role in neuronal excitability.Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation.The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels.A T-type channel-calmodulin complex triggers αCaMKII activation.[EXPRESS] Identification of interleukin-1 beta as a key mediator in the upregulation of Cav3.2-USP5 interactions in the pain pathwayIon mobility-mass spectrometry reveals conformational flexibility in the deubiquitinating enzyme USP5.The R18 Polyarginine Peptide Is More Effective Than the TAT-NR2B9c (NA-1) Peptide When Administered 60 Minutes after Permanent Middle Cerebral Artery Occlusion in the Rat.T-type channels: release a brake, engage a gear.A common haplotype containing functional CACNA1H variants is frequently coinherited with increased TPSAB1 copy number.Poly-arginine and arginine-rich peptides are neuroprotective in stroke models.The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms.Noradrenaline upregulates T-type calcium channels in rat pinealocytes.Characterisation of neuroprotective efficacy of modified poly-arginine-9 (R9) peptides using a neuronal glutamic acid excitotoxicity model.The tao of IGF-1: insulin-like growth factor receptor activation increases pain by enhancing T-type calcium channel activity.Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat.Looking for answers to L-type calcium channels in the ageing brain (Commentary on Zanos et al.).Cooperative roles of glucose and asparagine-linked glycosylation in T-type calcium channel expression.Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies.T-type calcium channels functionally interact with spectrin (α/β) and ankyrin B.Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila.A bright future? Optogenetics in the periphery for pain research and therapy
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P2860
The deubiquitinating enzyme USP5 modulates neuropathic and inflammatory pain by enhancing Cav3.2 channel activity.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
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2014年學術文章
@zh-hant
name
The deubiquitinating enzyme US ...... ncing Cav3.2 channel activity.
@en
The deubiquitinating enzyme US ...... ncing Cav3.2 channel activity.
@nl
type
label
The deubiquitinating enzyme US ...... ncing Cav3.2 channel activity.
@en
The deubiquitinating enzyme US ...... ncing Cav3.2 channel activity.
@nl
prefLabel
The deubiquitinating enzyme US ...... ncing Cav3.2 channel activity.
@en
The deubiquitinating enzyme US ...... ncing Cav3.2 channel activity.
@nl
P2093
P50
P1433
P1476
The deubiquitinating enzyme US ...... ancing Cav3.2 channel activity
@en
P2093
Agustin García-Caballero
Ivana A Souza
Jawed Hamid
Mickael Deage
Patrick Stemkowski
Victoria Hodgkinson
Vinicius M Gadotti
P304
P356
10.1016/J.NEURON.2014.07.036
P407
P577
2014-09-01T00:00:00Z