ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.
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Recent progress in the discovery of small molecules for the treatment of amyotrophic lateral sclerosis (ALS)Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Proteasome activation is a mechanism for pyrazolone small molecules displaying therapeutic potential in amyotrophic lateral sclerosisCrystal structure of ethyl 2-({[(4Z)-3,5-dioxo-1-phenyl-pyrazolidin-4-yl-idene]meth-yl}amino)-acetate.Direct amination of γ-halo-β-ketoesters with anilines.Tertiary Amine Pyrazolones and Their Salts as Inhibitors of Mutant Superoxide Dismutase 1-Dependent Protein Aggregation for the Treatment of Amyotrophic Lateral Sclerosis.Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS.A novel synthesis of 1-aryl-3-piperidone derivativesArylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis.Current Therapy of Drugs in Amyotrophic Lateral Sclerosis.Synthesis of some novel 4-arylidene pyrazoles as potential antimicrobial agents.A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity.
P2860
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P2860
ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.
description
2011 nî lūn-bûn
@nan
2011年の論文
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2011年学术文章
@wuu
2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
ADME-guided design and synthes ...... amyotrophic lateral sclerosis.
@en
ADME-guided design and synthes ...... mutant superoxide dismutase 1
@nl
type
label
ADME-guided design and synthes ...... amyotrophic lateral sclerosis.
@en
ADME-guided design and synthes ...... mutant superoxide dismutase 1
@nl
prefLabel
ADME-guided design and synthes ...... amyotrophic lateral sclerosis.
@en
ADME-guided design and synthes ...... mutant superoxide dismutase 1
@nl
P2093
P356
P1476
ADME-guided design and synthes ...... amyotrophic lateral sclerosis.
@en
P2093
Daniel Amante
Donald R Kirsch
Karen Smith
Radhia Benmohamed
Richard B Silverman
Richard I Morimoto
P304
P356
10.1021/JM2014277
P407
P577
2011-12-22T00:00:00Z