Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility.
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Androgen Receptor Structure, Function and Biology: From Bench to BedsideHeterozygous deletion of ventral anterior homeobox (vax1) causes subfertility in miceConditional knockout of the androgen receptor in gonadotropes reveals crucial roles for androgen in gonadotropin synthesis and surge in female mice.Androgen receptor (AR) physiological roles in male and female reproductive systems: lessons learned from AR-knockout mice lacking AR in selective cellsIdentification of androgen receptor phosphorylation in the primate ovary in vivo.Granulosa cell-specific androgen receptors are critical regulators of ovarian development and function.The androgen receptor mediates antiapoptotic function in myometrial cellsMolecular mechanisms of sex determination in reptiles.Orphan nuclear receptor Nur77 regulates androgen receptor gene expression in mouse ovaryMacronutrient balance, reproductive function, and lifespan in aging mice.Alternative splicing of the androgen receptor in polycystic ovary syndrome.Abnormal mitochondrial function and impaired granulosa cell differentiation in androgen receptor knockout mice.The androgen receptor confers protection against diet-induced atherosclerosis, obesity, and dyslipidemia in female miceAndrogens promote the acquisition of maturation competence in bovine oocytes.Intracrine Androgens Enhance Decidualization and Modulate Expression of Human Endometrial Receptivity GenesStuI polymorphism on the androgen receptor gene is associated with recurrent spontaneous abortion.Androgen actions and the ovary.The skeleton gets a (reproductive) life.Subfertile female androgen receptor knockout mice exhibit defects in neuroendocrine signaling, intraovarian function, and uterine development but not uterine function.Inactivation of the androgen receptor in bone-forming cells leads to trabecular bone loss in adult female mice.Identification of polycystic ovary syndrome potential drug targets based on pathobiological similarity in the protein-protein interaction network.Androgens regulate ovarian follicular development by increasing follicle stimulating hormone receptor and microRNA-125b expression.Genetics of androgen metabolism in women with infertility and hypoandrogenism.The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited.Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome.The Steroid Metabolome in the Isolated Ovarian Follicle and Its Response to Androgen Exposure and Antagonism.Effects of dehydroepiandrosterone on in vivo ovine follicular development.Androgens modulate the morphological characteristics of human endometrial stromal cells decidualized in vitro.Characterizing the neuroendocrine and ovarian defects of androgen receptor-knockout female mice.Development and Characterization of Uterine Glandular Epithelium Specific Androgen Receptor Knockout Mouse Model.Targeted loss of androgen receptor signaling in murine granulosa cells of preantral and antral follicles causes female subfertility.Androgens Regulate Ovarian Gene Expression Through Modulation of Ezh2 Expression and Activity.Androgen actions in mouse wound healing: Minimal in vivo effects of local antiandrogen delivery.In Vivo Evidence of the Androgen Receptor in Association With Myometrial Cell Proliferation and Apoptosis.Androgen receptor actions modify skin structure and chemical carcinogen-induced skin cancer susceptibility in mice.Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors."Positive Regulation of RNA Metabolic Process" Ontology Group Highly Regulated in Porcine Oocytes Matured In Vitro: A Microarray Approach.Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration.Zebrafish androgen receptor is required for spermatogenesis and maintenance of ovarian function.
P2860
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P2860
Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
@zh
2007年學術文章
@zh-hant
name
Female mice haploinsufficient ...... ent, ovulation, and fertility.
@en
Female mice haploinsufficient ...... ent, ovulation, and fertility.
@nl
type
label
Female mice haploinsufficient ...... ent, ovulation, and fertility.
@en
Female mice haploinsufficient ...... ent, ovulation, and fertility.
@nl
prefLabel
Female mice haploinsufficient ...... ent, ovulation, and fertility.
@en
Female mice haploinsufficient ...... ent, ovulation, and fertility.
@nl
P2093
P356
P1433
P1476
Female mice haploinsufficient ...... ment, ovulation, and fertility
@en
P2093
P304
P356
10.1210/EN.2007-0248
P407
P577
2007-04-26T00:00:00Z