Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries).
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Epithelial and ectomesenchymal role of the type I TGF-beta receptor ALK5 during facial morphogenesis and palatal fusionHypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene.Posttranslational processing of mouse and human BMP-15: potential implication in the determination of ovulation quotaThe role of transforming growth factor-beta (TGF-beta) during ovarian follicular development in sheepA Major Gene for Bovine Ovulation RateA 660-Kb deletion with antagonistic effects on fertility and milk production segregates at high frequency in Nordic Red cattle: additional evidence for the common occurrence of balancing selection in livestockDirect evidence on the contribution of a missense mutation in GDF9 to variation in ovulation rate of FinnsheepFunctional and molecular characterization of naturally occurring mutations in the oocyte-secreted factors bone morphogenetic protein-15 and growth and differentiation factor-9Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice.Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activitiesEvolutionary genetics and implications of small size and twinning in callitrichine primatesOocyte-specific overexpression of mouse bone morphogenetic protein-15 leads to accelerated folliculogenesis and an early onset of acyclicity in transgenic mice.Heterozygote advantage for fecundity.Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes.BMP15 suppresses progesterone production by down-regulating StAR via ALK3 in human granulosa cells.Identification and characterization of microRNAs in the ovaries of multiple and uniparous goats (Capra hircus) during follicular phase.FecX Bar a Novel BMP15 mutation responsible for prolificacy and female sterility in Tunisian Barbarine Sheep.Bone morphogenetic protein 15 in the pro-mature complex form enhances bovine oocyte developmental competenceA genome wide linkage scan for dizygotic twinning in 525 families of mothers of dizygotic twins.Impaired production of BMP-15 and GDF-9 mature proteins derived from proproteins WITH mutations in the proregion.Fibrillins in adult human ovary and polycystic ovary syndrome: is fibrillin-3 affected in PCOS?Selection in action: dissecting the molecular underpinnings of the increasing muscle mass of Belgian Blue CattleMouse fertility is enhanced by oocyte-specific loss of core 1-derived O-glycans.The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders.A missense mutation in growth differentiation factor 9 (GDF9) is strongly associated with litter size in sheepZygote arrest 1 gene in pig, cattle and human: evidence of different transcript variants in male and female germ cells.Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheepEffects of the FecL major gene in the Lacaune meat sheep population.Expression of maternally derived KHDC3, NLRP5, OOEP and TLE6 is associated with oocyte developmental competence in the ovine speciesSmad signalling in the ovaryAnimal transgenesis: state of the art and applications.Integral role of GDF-9 and BMP-15 in ovarian function.Genome-wide association studies identify two novel BMP15 mutations responsible for an atypical hyperprolificacy phenotype in sheepQuantitative analysis of bone morphogenetic protein 15 (BMP15) and growth differentiation factor 9 (GDF9) gene expression in calf and adult bovine ovariesRole of oocyte-derived paracrine factors in follicular development.A unique preovulatory expression pattern plays a key role in the physiological functions of BMP-15 in the mouseDesigning, optimization and validation of tetra-primer ARMS PCR protocol for genotyping mutations in caprine Fec genes.Regulation of ovulation rate in mammals: contribution of sheep genetic models.The highly prolific phenotype of Lacaune sheep is associated with an ectopic expression of the B4GALNT2 gene within the ovaryPositive selection in bone morphogenetic protein 15 targets a natural mutation associated with primary ovarian insufficiency in human.
P2860
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P2860
Mutations in the genes for oocyte-derived growth factors GDF9 and BMP15 are associated with both increased ovulation rate and sterility in Cambridge and Belclare sheep (Ovis aries).
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
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name
Mutations in the genes for ooc ...... d Belclare sheep (Ovis aries).
@en
Mutations in the genes for ooc ...... n Cambridge and Belclare sheep
@nl
type
label
Mutations in the genes for ooc ...... d Belclare sheep (Ovis aries).
@en
Mutations in the genes for ooc ...... n Cambridge and Belclare sheep
@nl
prefLabel
Mutations in the genes for ooc ...... d Belclare sheep (Ovis aries).
@en
Mutations in the genes for ooc ...... n Cambridge and Belclare sheep
@nl
P2093
P2860
P1476
Mutations in the genes for ooc ...... d Belclare sheep (Ovis aries).
@en
P2093
George H Davis
James P Hanrahan
Michael Mullen
Philippe Mulsant
Richard Powell
Scott M Gregan
Susan M Galloway
P2860
P304
P356
10.1095/BIOLREPROD.103.023093
P407
P577
2003-11-19T00:00:00Z