Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
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XLID-causing mutations and associated genes challenged in light of data from large-scale human exome sequencingRho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and diseaseThe molecular basis of cognitive deficits in pervasive developmental disordersActin-Dependent Alterations of Dendritic Spine Morphology in ShankopathiesGlobularity and language-readiness: generating new predictions by expanding the set of genes of interestMicrocephaly-dystonia due to mutated PLEKHG2 with impaired actin polymerization.Identification of a Protein Network Driving Neuritogenesis of MGE-Derived GABAergic Interneurons.αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor ReceptorDisruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalitiesIntellectual disability and autism spectrum disorders: causal genes and molecular mechanisms.Dileucine and PDZ-binding motifs mediate synaptic adhesion-like molecule 1 (SALM1) trafficking in hippocampal neurons1-42 β-amyloid peptide requires PDK1/nPKC/Rac 1 pathway to induce neuronal death.Changes in the GEF-H1 pathways after traumatic brain injury.The neurobiology of X-linked intellectual disability.Dendritic spines: the locus of structural and functional plasticity.RhoGEFs in cell motility: novel links between Rgnef and focal adhesion kinase.Roles of Rac1 and Rac3 GTPases during the development of cortical and hippocampal GABAergic interneuronsArhgef7 promotes activation of the Hippo pathway core kinase LatsRegulating Rac in the nervous system: molecular function and disease implication of Rac GEFs and GAPs.5-Fluorouracil chemotherapy upregulates cytokines and alters hippocampal dendritic complexity in aged mice.Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampusIncorrect dosage of IQSEC2, a known intellectual disability and epilepsy gene, disrupts dendritic spine morphogenesis.The Integrin-Mediated ILK-Parvin-αPix Signaling Axis Controls Differentiation in Mammary Epithelial Cells.Highly Expressed Genes within Hippocampal Sector CA1: Implications for the Physiology of Memory.Hippocampal dysfunction in the Euchromatin histone methyltransferase 1 heterozygous knockout mouse model for Kleefstra syndrome.Rho GTPases as therapeutic targets in Alzheimer's disease.Automated dissection of permanent effects of hippocampal or prefrontal lesions on performance at spatial, working memory and circadian timing tasks of C57BL/6 mice in IntelliCage.Reelin and the Cdc42/Rac1 guanine nucleotide exchange factor αPIX/Arhgef6 promote dendritic Golgi translocation in hippocampal neurons.Mice with experimental antiphospholipid syndrome display hippocampal dysfunction and a reduction of dendritic complexity in hippocampal CA1 neurones.Different roles of the small GTPases Rac1, Cdc42, and RhoG in CALEB/NGC-induced dendritic tree complexity.GIT1 regulates synaptic structural plasticity underlying learning.Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin dynamics.Rho GTPases in Intellectual Disability: From Genetics to Therapeutic Opportunities.Loss of ARHGEF6 Causes Hair Cell Stereocilia Deficits and Hearing Loss in MicePropofol Alters Long Non-Coding RNA Profiles in the Neonatal Mouse Hippocampus: Implication of Novel Mechanisms in Anesthetic-Induced Developmental Neurotoxicity
P2860
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P2860
Dysregulation of Rho GTPases in the αPix/Arhgef6 mouse model of X-linked intellectual disability is paralleled by impaired structural and synaptic plasticity and cognitive deficits.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh-hant
name
Dysregulation of Rho GTPases i ...... ticity and cognitive deficits.
@en
Dysregulation of Rho GTPases i ...... ticity and cognitive deficits.
@nl
type
label
Dysregulation of Rho GTPases i ...... ticity and cognitive deficits.
@en
Dysregulation of Rho GTPases i ...... ticity and cognitive deficits.
@nl
prefLabel
Dysregulation of Rho GTPases i ...... ticity and cognitive deficits.
@en
Dysregulation of Rho GTPases i ...... ticity and cognitive deficits.
@nl
P2093
P2860
P356
P1476
Dysregulation of Rho GTPases i ...... ticity and cognitive deficits.
@en
P2093
David Wolfer
Elly van Galen
Gabriele Rune
Georg Rosenberger
Ger J A Ramakers
Hans-Jürgen Kreienkamp
Harm J Krugers
Janine Prange-Kiel
Karin Richter
Kerstin Kuchenbecker
P2860
P304
P356
10.1093/HMG/DDR457
P577
2011-10-11T00:00:00Z