The effect of subunit composition of rat brain GABAA receptors on channel function.
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Human chromosomal localization of genes encoding the gamma 1 and gamma 2 subunits of the gamma-aminobutyric acid receptor indicates that members of this gene family are often clustered in the genomeGeneral anaesthetic actions on ligand-gated ion channelsAn initiator element mediates autologous downregulation of the human type A gamma -aminobutyric acid receptor beta 1 subunit genePWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in ratsPersistent depolarizing action of GABA in rat Cajal-Retzius cellsResponse kinetics and pharmacological properties of heteromeric receptors formed by coassembly of GABA rho- and gamma 2-subunitsPharmacology of GABA rho 1 and GABA alpha/beta receptors expressed in Xenopus oocytes and COS cellsStructure, function, and modulation of GABA(A) receptorsThe N-terminal domain of human GABA receptor rho1 subunits contains signals for homooligomeric and heterooligomeric interactionA novel positive allosteric modulator of the GABA(A) receptor: the action of (+)-ROD188Effects of gamma-HCH and delta-HCH on human recombinant GABA(A) receptors: dependence on GABA(A) receptor subunit combinationProton sensitivity of rat cerebellar granule cell GABAA receptors: dependence on neuronal developmentPositive allosteric modulation by ultraviolet irradiation on GABA(A), but not GABA(C), receptors expressed in Xenopus oocytesGABA-induced current and circadian regulation of chloride in neurones of the rat suprachiasmatic nucleusEffects of GABA(A) receptor partial agonists in primary cultures of cerebellar granule neurons and cerebral cortical neurons reflect different receptor subunit compositionsMethionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anestheticsMolecular basis of the γ-aminobutyric acid A receptor α3 subunit interaction with the clustering protein gephyrinThe third gamma subunit of the gamma-aminobutyric acid type A receptor familyIn the developing rat hippocampus a tonic GABAA-mediated conductance selectively enhances the glutamatergic drive of principal cellsAge-related GABAA receptor changes in rat auditory cortex.A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures.Five subtypes of type A gamma-aminobutyric acid receptors identified in neurons by double and triple immunofluorescence staining with subunit-specific antibodies.Curcumol allosterically modulates GABA(A) receptors in a manner distinct from benzodiazepines.A single amino acid in gamma-aminobutyric acid rho 1 receptors affects competitive and noncompetitive components of picrotoxin inhibitionNovel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?New insights into the mechanism of action of hypnotics.Diversity of structure and function of alpha1alpha6beta3delta GABAA receptors: comparison with alpha1beta3delta and alpha6beta3delta receptorsActivation and deactivation rates of recombinant GABA(A) receptor channels are dependent on alpha-subunit isoform.Point mutations affecting antagonist affinity and agonist dependent gating of GABAA receptor channels.Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity.Multiphasic desensitization of the GABAA receptor in outside-out patches.Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.Gamma-aminobutyric acid increases the water accessibility of M3 membrane-spanning segment residues in gamma-aminobutyric acid type A receptorsDown-regulation of GABA(A) receptor via promiscuity with the vasoactive peptide urotensin II receptor. Potential involvement in astrocyte plasticityFour amino acids in the alpha subunits determine the gamma-aminobutyric acid sensitivities of GABAA receptor subtypes.Assembly and cell surface expression of heteromeric and homomeric gamma-aminobutyric acid type A receptors.Simultaneous optical recording in multiple cells by digital holographic microscopy of chloride current associated to activation of the ligand-gated chloride channel GABA(A) receptor.Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?The effects of midazolam and sevoflurane on the GABA(A) receptors with alternatively spliced variants of the γ2 subunitHighly potent modulation of GABA(A) receptors by valerenic acid derivatives.
P2860
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P2860
The effect of subunit composition of rat brain GABAA receptors on channel function.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
The effect of subunit composition of rat brain GABAA receptors on channel function.
@en
The effect of subunit composition of rat brain GABAA receptors on channel function.
@nl
type
label
The effect of subunit composition of rat brain GABAA receptors on channel function.
@en
The effect of subunit composition of rat brain GABAA receptors on channel function.
@nl
prefLabel
The effect of subunit composition of rat brain GABAA receptors on channel function.
@en
The effect of subunit composition of rat brain GABAA receptors on channel function.
@nl
P2093
P1433
P1476
The effect of subunit composition of rat brain GABAA receptors on channel function.
@en
P2093
P304
P356
10.1016/0896-6273(90)90224-4
P407
P577
1990-11-01T00:00:00Z