GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element.
about
Pit-1 and GATA-2 interact and functionally cooperate to activate the thyrotropin beta-subunit promoterA Pit-1 threonine 220 phosphomimic reduces binding to monomeric DNA sites to inhibit Ras and estrogen stimulation of the prolactin gene promoterActivation of Go-coupled dopamine D2 receptors inhibits ERK1/ERK2 in pituitary cells. A key step in the transcriptional suppression of the prolactin geneSelective inhibition of prolactin gene transcription by the ETS-2 repressor factor.Molecular interaction of BMP-4, TGF-beta, and estrogens in lactotrophs: impact on the PRL promoter.Regulation of Ets function by protein - protein interactions.A role for CREB binding protein and p300 transcriptional coactivators in Ets-1 transactivation functionsSignal transduction and the Ets family of transcription factors.Structural characterization of the PIT-1/ETS-1 interaction: PIT-1 phosphorylation regulates PIT-1/ETS-1 bindingPituitary Ets-1 and GABP bind to the growth factor regulatory sites of the rat prolactin promoter.Persistent ERK/MAPK activation promotes lactotrope differentiation and diminishes tumorigenic phenotype.Analysis of fluG mutations that affect light-dependent conidiation in Aspergillus nidulans.Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression.Protein and DNA contact surfaces that mediate the selective action of the Phox1 homeodomain at the c-fos serum response element.Molecular physiology of pituitary development: signaling and transcriptional networks.Characterization and functional analysis of the p42Ets-1 variant of the mouse Ets-1 transcription factor.Purification and mass spectrometric identification of GA-binding protein (GABP) as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter.Ras signaling and transcriptional synergy at a flexible Ets-1/Pit-1 composite DNA element is defined by the assembly of selective activation domains.The Pit-1 homeodomain and beta-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter.The Pit-1beta domain dictates active repression and alteration of histone acetylation of the proximal prolactin promoter.The Ets factor Etv1 interacts with Tpit protein for pituitary pro-opiomelanocortin (POMC) gene transcription.Functional components of fibroblast growth factor (FGF) signal transduction in pituitary cells. Identification of FGF response elements in the prolactin gene.
P2860
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P2860
GHF-1/Pit-1 functions as a cell-specific integrator of Ras signaling by targeting the Ras pathway to a composite Ets-1/GHF-1 response element.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh-hant
name
GHF-1/Pit-1 functions as a cel ...... Ets-1/GHF-1 response element.
@en
GHF-1/Pit-1 functions as a cel ...... Ets-1/GHF-1 response element.
@nl
type
label
GHF-1/Pit-1 functions as a cel ...... Ets-1/GHF-1 response element.
@en
GHF-1/Pit-1 functions as a cel ...... Ets-1/GHF-1 response element.
@nl
prefLabel
GHF-1/Pit-1 functions as a cel ...... Ets-1/GHF-1 response element.
@en
GHF-1/Pit-1 functions as a cel ...... Ets-1/GHF-1 response element.
@nl
P2093
P2860
P356
P1476
GHF-1/Pit-1 functions as a cel ...... Ets-1/GHF-1 response element.
@en
P2093
Bradford AP
Gutierrez-Hartmann A
P2860
P304
24639-24648
P356
10.1074/JBC.271.40.24639
P407
P577
1996-10-01T00:00:00Z