Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
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The G53D mutation in Kir6.2 (KCNJ11) is associated with neonatal diabetes and motor dysfunction in adulthood that is improved with sulfonylurea therapy.Impact of hypoglycemic agents on myocardial ischemic preconditioningGUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patientsEffects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channelGlimepiride block of cloned beta-cell, cardiac and smooth muscle K(ATP) channelsThe molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetesFunctional involvement of sulphonylurea receptor (SUR) type 1 and 2B in the activity of pig urethral ATP-sensitive K+ channels.Muscle KATP channels: recent insights to energy sensing and myoprotectionATP-sensitive K+ channels of vascular smooth muscle cells.Is impairment of ischaemic preconditioning by sulfonylurea drugs clinically important?Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression.Comparison of the micro- and macro-vascular effects of glimepiride and gliclazide in metformin-treated patients with Type 2 diabetes: a double-blind, crossover study.Kir6.2 activation by sulfonylurea receptors: a different mechanism of action for SUR1 and SUR2A subunits via the same residues.Applying the Taguchi design for optimized formulation of sustained release gliclazide chitosan beads: an in vitro/in vivo studyVariations in tissue selectivity amongst insulin secretagogues: a systematic review.The therapeutic agents that target ATP-sensitive potassium channels.The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.Phosphatidylinositol 4,5-biphosphate (PIP2) modulates interaction of syntaxin-1A with sulfonylurea receptor 1 to regulate pancreatic β-cell ATP-sensitive potassium channels.Sulfonylureas suppress the stimulatory action of Mg-nucleotides on Kir6.2/SUR1 but not Kir6.2/SUR2A KATP channels: a mechanistic studyMolecular mechanism of sulphonylurea block of K(ATP) channels carrying mutations that impair ATP inhibition and cause neonatal diabetes.Differential effects of sulphonylureas on the vasodilatory response evoked by K(ATP) channel openers.Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel.
P2860
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P2860
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh-hant
name
Differential sensitivity of beta-cell and extrapancreatic K
@nl
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
@en
type
label
Differential sensitivity of beta-cell and extrapancreatic K
@nl
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
@en
prefLabel
Differential sensitivity of beta-cell and extrapancreatic K
@nl
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
@en
P356
P1433
P1476
Differential sensitivity of beta-cell and extrapancreatic K(ATP) channels to gliclazide.
@en
P2093
Ashcroft FM
Gribble FM
P2888
P304
P356
10.1007/S001250051236
P577
1999-07-01T00:00:00Z