Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.
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Oncogenic bystander radiation effects in Patched heterozygous mouse cerebellumThe miR-17~92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastomaAdaptations of energy metabolism during cerebellar neurogenesis are co-opted in medulloblastomaAberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cellsNovel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.Neurofibromatosis type 1 - a model for nervous system tumour formation?Subtypes of medulloblastoma have distinct developmental originsCerebellum development and medulloblastomaDevelopment and cancer of the cerebellumA distinct Smoothened mutation causes severe cerebellar developmental defects and medulloblastoma in a novel transgenic mouse modelIn vivo Mn-enhanced MRI for early tumor detection and growth rate analysis in a mouse medulloblastoma model.Primary cilia are required for cerebellar development and Shh-dependent expansion of progenitor pool.Developmental and oncogenic effects of insulin-like growth factor-I in Ptc1+/- mouse cerebellum.Bortezomib reverses a post-translational mechanism of tumorigenesis for patched1 haploinsufficiency in medulloblastoma.The p53 inhibitor MDM2 facilitates Sonic Hedgehog-mediated tumorigenesis and influences cerebellar foliationRole of the miR-17∼92 cluster family in cerebellar and medulloblastoma development.The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation.Sonic hedgehog-induced histone deacetylase activation is required for cerebellar granule precursor hyperplasia in medulloblastoma.WNT3 inhibits cerebellar granule neuron progenitor proliferation and medulloblastoma formation via MAPK activation.Survivin as a therapeutic target in Sonic hedgehog-driven medulloblastomaSerpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma.Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells.Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modellingLoss of cyclin D1 impairs cerebellar development and suppresses medulloblastoma formation.Overexpression of mutant Ptch in rhabdomyosarcomas is associated with promoter hypomethylation and increased Gli1 and H3K4me3 occupancy.WNT signaling increases proliferation and impairs differentiation of stem cells in the developing cerebellum.Targeting brain tumor cAMP: the case for sex-specific therapeuticsPrimary Cilia in the Murine Cerebellum and in Mutant Models of Medulloblastoma.A Mathematical Model of Granule Cell Generation During Mouse Cerebellum DevelopmentNuclear factor one transcription factors: Divergent functions in developmental versus adult stem cell populations.Bax deficiency prolongs cerebellar neurogenesis, accelerates medulloblastoma formation and paradoxically increases both malignancy and differentiation.Cell Division Mode Change Mediates the Regulation of Cerebellar Granule Neurogenesis Controlled by the Sonic Hedgehog Signaling.Hedgehog regulates cerebellar progenitor cell and medulloblastoma apoptosis.Review: In vivo models for defining molecular subtypes of the primitive neuroectodermal tumor genome: current challenges and solutions.Formation of telomeric repeat-containing RNA (TERRA) foci in highly proliferating mouse cerebellar neuronal progenitors and medulloblastoma.Targeting stem cells in brain tumors.Cooperation between the Hic1 and Ptch1 tumor suppressors in medulloblastoma.The role of microRNAs during the genesis of medulloblastomas induced by the hedgehog pathwayDifferential Apaf-1 levels allow cytochrome c to induce apoptosis in brain tumors but not in normal neural tissues.WIP1 enhances tumor formation in a sonic hedgehog-dependent model of medulloblastoma.
P2860
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P2860
Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh-hant
name
Loss of patched and disruption ...... stic stage of medulloblastoma.
@en
Loss of patched and disruption ...... stic stage of medulloblastoma.
@nl
type
label
Loss of patched and disruption ...... stic stage of medulloblastoma.
@en
Loss of patched and disruption ...... stic stage of medulloblastoma.
@nl
prefLabel
Loss of patched and disruption ...... stic stage of medulloblastoma.
@en
Loss of patched and disruption ...... stic stage of medulloblastoma.
@nl
P2093
P356
P1433
P1476
Loss of patched and disruption ...... astic stage of medulloblastoma
@en
P2093
Anriada Mehmeti
Jessica D Kessler
Jonathan F Wells
Robert J Wechsler-Reya
Simon M Lin
Trang T T Huynh
P304
P356
10.1242/DEV.01793
P407
P577
2005-04-20T00:00:00Z