Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.
about
Crystal structure of the human two-pore domain potassium channel K2P1Scorpion toxin block of the early K+ current (IKf) in rat dorsal root ganglion neuronesElectrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels.Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.Solution structure of GxTX-1E, a high-affinity tarantula toxin interacting with voltage sensors in Kv2.1 potassium channelsInteractions between lipids and voltage sensor paddles detected with tarantula toxinsChemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxinsBinding of a gating modifier toxin induces intersubunit cooperativity early in the Shaker K channel's activation pathwayFrom foe to friend: using animal toxins to investigate ion channel functionMolecular bases of NMDA receptor subtype-dependent propertiesStructural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: Solution structure of the potassium channel inhibitor HsTX1Solution structure of BmKTX, a K+ blocker toxin from the Chinese scorpion Buthus MartensiLocal complexity of amino acid interactions in a protein coreStructure and Assembly Mechanism for Heteromeric Kainate ReceptorsUnstructured to structured transition of an intrinsically disordered protein peptide in coupling Ca2+-sensing and SK channel activationStructure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K + channelCrystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and CalmodulinEvidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptorCloning and characterization of novel snake venom proteins that block smooth muscle contractionModeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cyclesIon-channel modulators: more diversity than previously thoughtThe D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferationA shared mechanism for lipid- and beta-subunit-coordinated stabilization of the activated K+ channel voltage sensorSolution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometryEvolutionary information for specifying a protein foldCharacterization of a new peptide from Tityus serrulatus scorpion venom which is a ligand of the apamin-binding siteMechanism of Ba(2+) block of a mouse inwardly rectifying K+ channel: differential contribution by two discrete residuesAromatics at the murine nicotinic receptor agonist binding site: mutational analysis of the alphaY93 and alphaW149 residuesSelection of inhibitor-resistant viral potassium channels identifies a selectivity filter site that affects barium and amantadine blockInteraction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channelsThe nature of protein domain evolution: shaping the interaction networkRefined solution structure of the anti-mammal and anti-insect LqqIII scorpion toxin: comparison with other scorpion toxins.A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierolKalium: a database of potassium channel toxins from scorpion venom.A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.A single GluN2 subunit residue controls NMDA receptor channel properties via intersubunit interaction.Purification, characterization and biosynthesis of parabutoxin 3, a component of Parabuthus transvaalicus venom.Sequence analysis of an artificial family of RNA-binding peptidesAn activation switch in the ligand binding pocket of the C5a receptor.Convergent evolution with combinatorial peptides.
P2860
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P2860
Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年学术文章
@wuu
1995年学术文章
@zh
1995年学术文章
@zh-cn
1995年学术文章
@zh-hans
1995年学术文章
@zh-my
1995年学术文章
@zh-sg
1995年學術文章
@yue
1995年學術文章
@zh-hant
name
Revealing the architecture of ...... cles with a peptide inhibitor.
@en
Revealing the architecture of ...... cles with a peptide inhibitor.
@nl
type
label
Revealing the architecture of ...... cles with a peptide inhibitor.
@en
Revealing the architecture of ...... cles with a peptide inhibitor.
@nl
prefLabel
Revealing the architecture of ...... cles with a peptide inhibitor.
@en
Revealing the architecture of ...... cles with a peptide inhibitor.
@nl
P356
P1433
P1476
Revealing the architecture of ...... ycles with a peptide inhibitor
@en
P2093
R MacKinnon
P304
P356
10.1126/SCIENCE.7716527
P407
P577
1995-04-01T00:00:00Z